HIV-1 Infection and Antibodies to Plasmodium falciparum in Adults
HIV-1 Infection and Antibodies to Plasmodium falciparum in Adults
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DOI：
10.1093/infdis/jiu262
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发表时间：
2014-11-01
影响因子：
6.4
通讯作者：
Rogerson, Stephen
中科院分区：
文献类型：
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作者：
Hasang, Wina;Dembo, Edson G.;Rogerson, Stephen
背景资料。与人类免疫缺陷病毒(HIV)混合感染可能会损害自然获得性免疫，从而增加疟疾的易感性。用恶性疟原虫FCR3、E8b和R29三株寄生虫株和裂殖子抗原AMA-1和MSP2对339例成人(感染HIV)进行了检测。我们确定了疟疾抗体、HIV感染、免疫妥协标记物和寄生虫病发病风险之间的关系。HIV感染的成人对所有寄生虫株的调理抗体平均水平显著降低(P<；.0001)，对AMA-1(P=.01)和MSP2的抗体水平(P<；.0001)显著降低。免疫球蛋白G(Ig G)对VSA的水平不受HIV状态的影响。对某些分离株的有利抗体滴度与CD_4计数呈正相关。人类免疫缺陷病毒1型(HIV-1)病毒载量与FCR3调理抗体呈负相关(P=0.04)，与AMA-1抗体呈负相关(P<0.05)。
Background. Coinfection with human immunodeficiency virus (HIV) may increase susceptibility to malaria by compromising naturally acquired immunity.Methods. In 339 adults (64% HIV infected), we measured antibodies to Plasmodium falciparum variant surface antigens (VSA) and antibodies that opsonise infected erythrocytes using parasite lines FCR3, E8B, and R29, and antibodies to merozoite antigens AMA-1 and MSP2. We determined the relationship between malaria antibodies, HIV infection, markers of immune compromise, and risk of incident parasitemia.Results. HIV-infected adults had significantly lower mean levels of opsonizing antibody to all parasite lines (P < .0001), and lower levels of antibody to AMA-1 (P = .01) and MSP2 (P < .0001). Levels of immunoglobulin G (IgG) to VSA were not affected by HIV status. Opsonising antibody titres against some isolates were positively correlated with CD4 count. There were negative associations between human immunodeficiency virus type 1 (HIV-1) viral load and opsonizing antibodies to FCR3 (P = .04), and levels of IgG to AMA-1 (P