Incidence and risk factors for serious hypoglycemia in older persons using insulin or sulfonylureas
Incidence and risk factors for serious hypoglycemia in older persons using insulin or sulfonylureas
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DOI：
10.1001/archinte.157.15.1681
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发表时间：
1997-08-11
影响因子：
--
通讯作者：
Griffin, MR
中科院分区：
文献类型：
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作者：
Shorr, RI;Ray, WA;Griffin, MR
背景资料：我们对糖尿病治疗相关的低血糖风险的了解来自于经常排除虚弱的老年人的研究。目的：确定使用磺脲类药物或胰岛素的老年人发生严重低血糖的发病率和危险因素。方法：我们对19932名年龄在65岁或以上的田纳西州医疗补助登记者进行了一项基于人群的回顾性队列研究，从1985年到1989年使用过胰岛素或磺脲类药物。主要终点是严重低血糖，定义为住院、急诊或与低血糖症状相关的死亡，同时血糖测定低于2.8 mmol/L（
Background: Our knowledge about the risk of hypoglycemia associated with diabetes treatment is derived from studies that often exclude frail, elderly persons.Objective: To determine the incidence and risk factors for developing serious hypoglycemia among older persons using sulfonylureas or insulin.Methods: We conducted a population-based, retrospective cohort study of 19 932 Tennessee Medicaid enrollees, aged 65 years or older, who used insulin or sulfonylureas from 1985 through 1989. The main end point was serious hypoglycemia defined as a hospitalization, emergency department admission, or death associated with hypoglycemic symptoms and a concomitant blood glucose determination of less than 2.8 mmol/L (