Clonality and altered behavior of endothelial cells from hemangiomas
Clonality and altered behavior of endothelial cells from hemangiomas
复制标题
DOI：
10.1172/jci11432
复制
发表时间：
2001-03-01
影响因子：
15.9
通讯作者：
Bischoff, J
中科院分区：
文献类型：
--
作者：
Boye, E;Yu, Y;Bischoff, J
血管瘤是婴儿期最常见的肿瘤，是一种病因不明的良性血管肿瘤。据我们所知，我们首次证明了来自增殖性血管瘤的内皮细胞是克隆的，并且我们证明了这些血管瘤来源的细胞在体外增殖和迁移的速度上不同于正常的内皮细胞。此外，血管生成抑制剂内皮抑素可以刺激血管瘤内皮细胞的迁移，这与正常内皮细胞的抑制作用不同。我们认为血管瘤是内皮细胞的克隆扩增。这与这些肿瘤是由调节内皮细胞增殖的一个或多个基因的体细胞突变引起的可能性是一致的。
Hemangioma, the most common tumor of infancy, is a benign vascular neoplasm of unknown etiology. We show, for the first time to our knowledge, that endothelial cells from proliferating hemangioma are clonal, and we demonstrate that these hemangioma-derived cells differ from normal endothelial cells in their rates of proliferation and migration in vitro. Furthermore, migration of hemangioma endothelial cells is stimulated by the angiogenesis inhibitor endostatin, unlike the inhibition seen with normal endothelial cells. We conclude that hemangiomas constitute clonal expansions of endothelial cells. This is consistent with the possibility that these tumors are caused by somatic mutations in one or more genes regulating endothelial cell proliferation.