An adipocentric perspective of resveratrol as a calorie restriction mimetic
An adipocentric perspective of resveratrol as a calorie restriction mimetic
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DOI：
10.1111/nyas.12212
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发表时间：
2013-01-01
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影响因子：
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通讯作者：
Barger, Jamie L.
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文献类型：
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作者：
Barger, Jamie L.
脂肪组织是一种活跃的内分泌器官，对能量平衡的变化作出反应，影响全身生理。肥胖的脂肪组织功能障碍与代谢性疾病、神经变性、炎症和癌症有关，而热量限制（CR）可以降低肥胖和疾病风险。虽然白藜芦醇不影响肥胖，但它通过增加模式生物的寿命和啮齿动物的健康寿命来模拟长期CR。由于白藜芦醇对实验动物的益处让人联想到CR下脂肪组织功能的改善，因此本文综合现有数据来评估白藜芦醇的作用是否可能通过模拟脂肪组织中的CR来介导。在代谢不健康的人群中，白藜芦醇的摄入重现了CR的健康益处，而在其他健康人群中，短期白藜芦醇在转录水平上模仿CR，而不是生理水平。后一种观察（短期白藜芦醇的中性作用）可能对未来的疾病风险有保护作用；然而，需要在健康人群中进行长期研究来支持这一假设。
Adipose tissue is an active endocrine organ that responds to changes in energy balance and influences whole-body physiology. Adipose tissue dysfunction with obesity is associated with metabolic disease, neurodegeneration, inflammation, and cancer, whereas calorie restriction (CR) decreases both adiposity and disease risk. Although resveratrol does not affect obesity, it mimics long-term CR by increasing both life span in model organisms and health span in rodents. Because resveratrol's benefits in experimental animals are reminiscent of improved adipose tissue function under CR, this review synthesizes existing data to assess if resveratrol's effects may be mediated by mimicking CR in adipose tissue. In metabolically unhealthy humans, resveratrol consumption recapitulates the health benefits of CR, whereas short-term resveratrol in otherwise healthy humans mimics CR at the transcriptional, but not physiological, level. This latter observation (neutral effect of short-term resveratrol) may be protective against future disease risk; however, long-term studies in healthy humans will be needed to support this hypothesis.