Clonal T-cell populations in lymphomatoid papulosis. Evidence of a lymphoproliferative origin for a clinically benign disease.
Clonal T-cell populations in lymphomatoid papulosis. Evidence of a lymphoproliferative origin for a clinically benign disease.
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淋巴瘤样丘疹病中的克隆 T 细胞群。
DOI：
10.1056/nejm198608213150802
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Sklar,J
中科院分区：
文献类型：
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作者：
Weiss,LM;Wood,GS;Trela,M;Warnke,RA;Sklar,J
淋巴瘤样丘疹是一种慢性的、临床上良性的皮肤疾病，当组织学检查时，可以看到包括许多显示T淋巴细胞抗原标记的大的、不典型的淋巴样细胞。为了研究这种疾病的临床表现与其恶性组织学表现之间的差异，我们分析了6名患者皮损中的DNA，以检测β和γT细胞受体基因的重排。其中五名患者的病变显示至少一个T细胞受体基因有一到三个克隆性重排。来自一名患者的三个单独的活检样本显示，每个样本中的β基因重排模式不同。我们的结果表明，淋巴瘤样丘疹是一种克隆性T细胞淋巴增殖过程，可能起源于多克隆。我们得出结论，尽管其病程缓慢，但该疾病具有与恶性T细胞肿瘤一致的生物学和组织学特征。(《英国医学杂志》1986；315：475-9)
Lymphomatoid papulosis is a chronic, clinically benign skin disorder that, when examined histologically, is seen to include numerous large, atypical lymphoid cells that display antigenic markers of T lymphocytes. To investigate the disparity between the clinical behavior of this disease and its malignant histologic appearance, we analyzed the DNA from skin lesions of six patients for rearrangements of beta and gamma T-cell receptor genes. Lesions from five of these patients showed between one and three clonal rearrangements for at least one T-cell receptor gene. Three separate biopsy specimens from a single patient showed different patterns of rearrangements for the beta gene in each specimen. Our results indicate that lymphomatoid papulosis is a clonal T-cell lymphoproliferative process that may possibly be multiclonal in origin.We conclude that this disease has both biologic and histologic features consistent with a malignant T-cell neoplasm despite its indolent course. (N Engl J Med 1986; 315:475–9.)