Influenza Sentinel Surveillance among Patients with Influenza-Like-Illness and Severe Acute Respiratory Illness within the Framework of the National Reference Laboratory, Niger, 2009-2013.
Influenza Sentinel Surveillance among Patients with Influenza-Like-Illness and Severe Acute Respiratory Illness within the Framework of the National Reference Laboratory, Niger, 2009-2013.
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DOI：
10.1371/journal.pone.0133178
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Oukem-Boyer OO
中科院分区：
文献类型：
--
作者：
Maïnassara HB;Lagare A;Tempia S;Sidiki A;Issaka B;Abdou Sidikou B;Oukem-Boyer OO
人们对包括尼日尔在内的非洲的流感流行病学知之甚少。我们记录了 2009 年 4 月至 2013 年 4 月在尼日尔选定哨点就诊的流感样疾病 (ILI) 门诊患者和严重急性呼吸道疾病 (SARI) 住院患者中季节性和大流行性流感的流行病学。符合 ILI 或 SARI 病例定义并在选定哨点站点门诊或住院部就诊的患者均被纳入。收集流行病学数据和鼻咽拭子。通过实时逆转录聚合酶链反应测试呼吸道样本。 2009年4月至2013年4月，获得了1176例流感样病例和952例严重急性呼吸道感染病例的实验室结果，其中分别有146例（12%）和54例（6%）流感病毒检测呈阳性。 5-14岁年龄组的流感阳性率最高（32/130；ILI患者为24%；SARI患者为6/61；SARI患者为10%），其次是1-4岁年龄组（69/438；ILI患者为16%；SARI患者为32/333；SARI患者为9%）。在 200 例流感阳性病例中，104 例 (52%) 为 A(H1N1)pdm09，62 例 (31%) 为 A(H3N2)，34 例 (17%) 为 B。流感病毒主要在 11 月至 4 月检测到，2 月观察到病毒活动高峰。尼日尔哨点监测系统能够监测季节性流感的传播以及甲型H1N1pdm09流感在该国的传入和传播。需要进行持续的流感监测，以更好地了解季节性流感的流行病学并监测具有大流行潜力的流感毒株的出现。
Little is known about the epidemiology of influenza in Africa, including Niger. We documented the epidemiology of seasonal and pandemic influenza among outpatients with influenza-like-illness (ILI) and inpatients with severe acute respiratory illness (SARI) presenting at selected sentinel sites in Niger from April 2009 through April 2013. Patients meeting the ILI or the SARI case definitions and presenting at the outpatient or inpatient departments of selected sentinel sites were enrolled. Epidemiological data and nasopharyngeal swabs were collected. The respiratory samples were tested by real-time reverse transcription polymerase chain reaction. From April 2009 to April 2013, laboratory results were obtained from 1176 ILI and 952 SARI cases, of which 146 (12%) and 54 (6%) tested positive for influenza virus, respectively. The influenza positivity rate was highest in the 5-14 year age-group (32/130; 24% among ILI patients and 6/61; 10% among SARI patients) followed by the 1-4 year age-group (69/438; 16% among ILI patients and 32/333; 9% among SARI patients). Of the 200 influenza positive cases 104 (52%) were A(H1N1)pdm09, 62 (31%) were A(H3N2) and 34 (17%) were B. Influenza viruses were detected predominantly from November to April with peak viral activity observed in February. The Niger sentinel surveillance system allowed to monitor the circulation of seasonal influenza as well as the introduction and spread of influenza A(H1N1)pdm09 in the country. Continuous influenza surveillance is needed to better understand the epidemiology of seasonal influenza and monitor the emergence of influenza strains with pandemic potential.