A compact neural recording interface based on silicon microelectrode
A compact neural recording interface based on silicon microelectrode
复制标题
DOI：
10.1007/s11431-013-5359-2
复制
发表时间：
2013-09
期刊：
影响因子：
--
通讯作者：
Jianqiang Han;Xu Zhang;Weihua Pei;Q. Gui;Ming Liu;Hongda Chen
中科院分区：
文献类型：
--
作者：
Jianqiang Han;Xu Zhang;Weihua Pei;Q. Gui;Ming Liu;Hongda Chen
研制了一种用于细胞外神经记录的混合式神经记录接口原型。它由硅基平面微电极阵列和CMOS低噪声神经放大器芯片组成。神经放大器芯片采用0.18 μm N阱CMOS 1P6M工艺设计实现。神经元面积仅为0.042 mm2，增益为48.3 dB。在4 kHz通带内，输入等效噪声为4.73 μVrms。为了避免高密度多通道神经记录接口的电缆束缚，使其紧凑，倒装芯片键合被用来集成在一起的可编程芯片和微电极。该混合装置的尺寸为3mm × 5.5mm ×330 μm，便于植入或活体神经记录。在体实验中验证了该混合装置的有效性。在麻醉的Sprague道利大鼠海马区成功记录到神经信号。
A prototype of hybrid neural recording interface has been developed for extracellular neural recording. It consists of a silicon-based plane microelectrode array and a CMOS low noise neural amplifier chip. The neural amplifier chip is designed and implemented in 0.18 μm N-well CMOS 1P6M technology. The area of the neural preamplifier is only 0.042 mm2with a gain of 48.3 dB. The input equivalent noise is 4.73 μVrms within pass bands of 4 kHz. To avoid cable tethering for high dense multichannel neural recording interface and make it compact, flip-chip bonding is used to integrate the preamplifier chip and the microelectrode together. The hybrid device measures 3 mm×5.5 mm×330 μm, which is convenient for implant orin-vivoneural recording. The hybrid device was testified inin-vivoexperiment. Neural signals were recorded from hippocampus region of anesthetized Sprague Dawley rats successfully.