Autoantibodies in lung cancer:: possibilities for early detection and subsequent cure
Autoantibodies in lung cancer:: possibilities for early detection and subsequent cure
复制标题
DOI：
10.1136/thx.2007.083592
复制
发表时间：
2008-03-01
期刊：
影响因子：
10
通讯作者：
Robertson, J. F.
中科院分区：
文献类型：
--
作者：
Chapman, C. J.;Murray, A.;Robertson, J. F.
背景：肺癌患者通常出现在疾病病程的晚期，此时他们的长期生存机会很低。目前，即使是在罹患该病的高危人群中，也几乎没有什么可以提供的早期诊断。目的：评价一组肿瘤相关自身抗体对其他肺癌筛查模式的帮助作用。方法：检测50例正常人、82例非小细胞肺癌患者和22例小细胞肺癌患者的血浆中抗P53、c-myc、HER2、NY-ESO-1、CAGE、HER2、NY-ESO-1的自身抗体。结果：76%的肺癌患者血浆中至少有1/7的自身抗体水平升高，89%的淋巴结阴性患者自身抗体水平升高，特异性为92%。虽然更多的鳞状细胞癌患者(92%)可以被识别出来，但肺癌亚型之间的检出率没有显著差异。结论：在优化的组间试验中，测定对一个或多个肿瘤相关抗原的自身抗体反应可能提供一种灵敏和特异的血液检测方法，以帮助肺癌的早期发现。
Background: People with lung cancer usually present at a late stage in the course of their disease when their chances of long-term survival are low. At present there is little to offer for early diagnosis, even in those at high risk of developing the disease. Autoantibodies have been shown to be present in the circulation of people with various forms of solid tumour before cancer-associated antigens can be detected, and these molecules can be measured up to 5 years before symptomatic disease.Objective: To assess the potential of a panel of tumour-associated autoantibody profiles as an aid to other lung cancer screening modalities.Methods: Plasma from normal controls (n = 50), patients with non-small cell lung cancer (n = 82) and patients with small cell lung cancer (n = 22) were investigated for the presence of autoantibodies to p53, c-myc, HER2, NY-ESO-1, CAGE, MUC1 and GBU4-5 by enzyme-linked immunosorbent assay.Results: Raised levels of autoantibodies were seen to at least 1/7 antigens in 76% of all the patients with lung cancer plasma tested, and 89% of node-negative patients, with a specificity of 92%. There was no significant difference between the detection rates in the lung cancer subgroups, although more patients with squamous cell carcinomas (92%) could be identified.Conclusion: Measurement of an autoantibody response to one or more tumour-associated antigens in an optimised panel assay may provide a sensitive and specific blood test to aid the early detection of lung cancer.