B cell regulation in cancer and anti-tumor immunity.
B cell regulation in cancer and anti-tumor immunity.
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DOI：
10.1038/cmi.2017.35
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发表时间：
2017-08
影响因子：
24.1
通讯作者：
Saudemont A
中科院分区：
文献类型：
--
作者：
Sarvaria A;Madrigal JA;Saudemont A
免疫效应细胞和免疫抑制细胞之间的平衡及其如何调节肿瘤微环境已得到很好的描述。免疫调节细胞（包括调节性 T 细胞）对肿瘤进展的重要贡献已被广泛报道。最近，越来越多的证据认识到 B 细胞在调节肿瘤和淋巴恶性肿瘤的免疫反应中的作用。调节性 B 细胞 (Breg) 是新指定的 B 细胞亚群，已被证明在调节与炎症、自身免疫以及最近的癌症有关的免疫反应中发挥着关键作用。 Bregs可以通过分泌IL-10等抗炎介质来抑制包括T细胞在内的多种细胞亚型，并可以促进T细胞向调节性T细胞的转化，从而减弱抗肿瘤免疫反应。据报道，类似的 B 细胞亚群被招募到肿瘤中，但在肿瘤床内获得其免疫抑制特性，从而减弱抗肿瘤免疫反应。然而，尽管 Bregs 在促进炎症和致癌方面发挥着关键作用，但 Bregs 特有的细胞表面标记物的表型多样性在小鼠和人类中仍不清楚。在这篇综述中，我们总结了 Bregs 的特点，并回顾了我们目前对 Bregs 的认识及其对小鼠肿瘤模型和癌症患者抗肿瘤免疫反应的抑制作用。
The balance between immune effector cells and immunosuppressive cells and how this regulates the tumor microenvironment has been well described. A significant contribution of immune regulatory cells, including regulatory T cells, to tumor progression has been widely reported. An emerging body of evidence has recently recognized a role for B cells in modulating the immune response to tumors and lymphoid malignancies. Regulatory B cells (Bregs) are a newly designated subset of B cells that have been shown to play a pivotal role in regulating immune responses involved in inflammation, autoimmunity and, more recently, cancer. Bregs can suppress diverse cell subtypes, including T cells, through the secretion of anti-inflammatory mediators, such as IL-10, and can facilitate the conversion of T cells to regulatory T cells, thus attenuating anti-tumor immune responses. Similar B-cell subpopulations have been reported to be recruited to the tumor but to acquire their immunosuppressive properties within the tumor bed and thereby attenuate anti-tumor immune responses. However, despite a pivotal role for Bregs in promoting inflammation and carcinogenesis, the phenotypic diversity of the cell surface markers that are unique to Bregs remains unclear in mice and humans. In this review, we summarize the characteristics of Bregs and review our current knowledge of Bregs and their inhibition of anti-tumor immune responses in murine tumor models and cancer patients.
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DOI：
10.4049/jimmunol.0803052
发表时间：
2009-03-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Blair PA;Chavez-Rueda KA;Evans JG;Shlomchik MJ;Eddaoudi A;Isenberg DA;Ehrenstein MR;Mauri C
通讯作者：
Mauri C
影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.4049/jimmunol.0903009
发表时间：
2010-04-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
DiLillo DJ;Yanaba K;Tedder TF
通讯作者：
Tedder TF
影响因子：
11.2
作者：
Domschke, Christoph;Schuetz, Florian;Beckhove, Philipp
通讯作者：
Beckhove, Philipp
影响因子：
4.4
作者：
Evans, Jamie G.;Chavez-Rueda, Karina A.;Mauri, Claudia
通讯作者：
Mauri, Claudia