Dietary glycemic index, dietary glycemic load, blood lipids, and C-reactive protein
Dietary glycemic index, dietary glycemic load, blood lipids, and C-reactive protein
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DOI：
10.1016/j.metabol.2007.11.002
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发表时间：
2008-03-01
影响因子：
9.8
通讯作者：
Liu, Simin
中科院分区：
文献类型：
--
作者：
Levitan, Emily B.;Cook, Nancy R.;Liu, Simin
碳水化合物的数量和质量可能会通过血脂浓度和炎症影响心血管疾病的风险。我们使用食物频率问卷调查了18137名年龄≥ 45岁、未诊断为糖尿病的健康女性的饮食血糖指数（GI）和饮食血糖负荷（GL）。我们检测了空腹总胆固醇、高密度脂蛋白（HDL）和低密度脂蛋白（LDL）胆固醇、LDL/HDL胆固醇比值、三酰甘油（TG）和C反应蛋白（CRP）。我们采用横断面设计，调整年龄、体重指数、生活方式因素和其他饮食因素，评估饮食GI和GL的相关性。饮食GI与HDL和LDL胆固醇、LDL/HDL胆固醇比、TG和CRP显著相关（比较HDL胆固醇= -2.6 mg/dL、LDL胆固醇= 2.2 mg/dL、LDL/HDL胆固醇比= 0.16、TG = 12 mg/dL和CRP = 0.21 mg/L的上五分位数差异）。饮食GL与HDL胆固醇、LDL/HDL胆固醇比和TG相关（比较顶部和底部五分位HDL胆固醇= -4.9 mg/dL，LDL/HDL胆固醇比= 0.24，TG = 13 mg/dL）。饮食GI和GL的极端五分位数之间的血脂和CRP差异很小，但可能转化为心血管风险的临床有意义的差异。(C)2008年爱思唯尔公司All rights reserved.
Carbohydrate quantity and quality may influence the risk of cardiovascular disease through blood lipid concentrations and inflammation. We measured dietary glycemic index (GI) and dietary glycemic load (GL) among 18137 healthy women >= 45 years old without diagnosed diabetes using a food-frequency questionnaire. We assayed fasting total, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) cholesterol; LDL/HDL cholesterol ratio; triacylglycerols (TG); and C-reactive protein (CRP). We evaluated associations with dietary GI and GL using a cross-sectional design, adjusting for age, body mass index, lifestyle factors, and other dietary factors. Dietary GI was significantly associated with HDL and LDL cholesterol, LDL/HDL cholesterol ratio, TG, and CRP (comparing top to bottom quintile difference in HDL cholesterol = -2.6 mg/dL, LDL cholesterol = 2.2 mg/dL, LDL/HDL cholesterol ratio = 0.16, TG = 12 mg/dL, and CRP = 0.21 mg/L). Dietary GL was associated with HDL cholesterol, LDL/HDL cholesterol ratio, and TG (comparing top to bottom quintile HDL cholesterol = -4.9 mg/dL, LDL/HDL cholesterol ratio = 0.24, and TG = 13 mg/dL). Differences in blood lipids and CRP between extreme quintiles of dietary GI and GL were small, but may translate into a clinically meaningful difference in cardiovascular risk. (C) 2008 Elsevier Inc. All rights reserved.