Choline intake and risk of lethal prostate cancer: incidence and survival
Choline intake and risk of lethal prostate cancer: incidence and survival
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DOI：
10.3945/ajcn.112.039784
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发表时间：
2012-10-01
影响因子：
7.1
通讯作者：
Chan, June M.
中科院分区：
文献类型：
--
作者：
Richman, Erin L.;Kenfield, Stacey A.;Chan, June M.
背景：肉类、牛奶和鸡蛋与晚期前列腺癌的风险之间的关系并不一致。这些食物是胆碱的来源，胆碱是一种营养素，可以通过细胞膜功能和一碳代谢影响前列腺癌的进展。没有研究已经检查了饮食胆碱和致命的prostate cancer.Objective的风险：我们的目的是检查是否饮食胆碱，含胆碱化合物，甜菜碱（胆碱代谢产物）增加致命的prostate cancer.Design的风险：我们前瞻性地检查了这些营养素的摄入量和致命的前列腺癌的风险之间的47,896名男性在卫生专业人员随访研究。在一项仅病例生存分析中，我们对4282名初次诊断为非转移性疾病的男性进行了随访，检查了这些营养素的诊断后摄入量和致命性前列腺癌的风险。在22年的随访中，我们用一份经过验证的问卷对饮食进行了6次评估。结果：在发病率分析中，我们在879,627人年中观察到695例致命的前列腺癌。胆碱摄入量最高的五分之一的男性患致命性前列腺癌的风险增加了70%（HR：1.70; 95% CI：1.18，2.45; P趋势= 0.005）。在仅病例生存分析中，我们在33，679人年中观察到271例致死病例。诊断后胆碱摄入量与致死性前列腺癌的风险无统计学显著相关性（五分位数5与五分位数1的HR：1.69; 95%CI：0.93，3.09; P趋势= 0.20）。结论：在我们研究人群中的47，896名男性中，胆碱摄入量与致死性前列腺癌的风险增加相关。美国临床营养杂志2012;96：855-63。
Background: Meat, milk, and eggs have been inconsistently associated with the risk of advanced prostate cancer. These foods are sources of choline-a nutrient that may affect prostate cancer progression through cell membrane function and one-carbon metabolism. No study has examined dietary choline and the risk of lethal prostate cancer.Objective: Our objective was to examine whether dietary choline, choline-containing compounds, and betaine (a choline metabolite) increase the risk of lethal prostate cancer.Design: We prospectively examined the intake of these nutrients and the risk of lethal prostate cancer among 47,896 men in the Health Professionals Follow-Up Study. In a case-only survival analysis, we examined the postdiagnostic intake of these nutrients and the risk of lethal prostate cancer among 4282 men with an initial diagnosis of nonmetastatic disease during follow-up. Diet was assessed with a validated questionnaire 6 times during 22 y of follow-up.Results: In the incidence analysis, we observed 695 lethal prostate cancers during 879,627 person-years. Men in the highest quintile of choline intake had a 70% increased risk of lethal prostate cancer (HR: 1.70; 95% CI: 1.18, 2.45; P-trend = 0.005). In the case-only survival analysis, we observed 271 lethal cases during 33,679 person-years. Postdiagnostic choline intake was not statistically significantly associated with the risk of lethal prostate cancer (HR for quintile 5 compared with quintile 1: 1.69; 95% CI: 0.93, 3.09; P-trend = 0.20).Conclusion: Of the 47,896 men in our study population, choline intake was associated with an increased risk of lethal prostate cancer. Am J Clin Nutr 2012;96:855-63.