Evidence for a selective sweep in the wapl region of Drosophila melanogaster
Evidence for a selective sweep in the wapl region of Drosophila melanogaster
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DOI：
10.1534/genetics.105.049346
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发表时间：
2006-01-01
期刊：
影响因子：
3.3
通讯作者：
De Lorenzo, D
中科院分区：
文献类型：
--
作者：
Beisswanger, S;Stephan, W;De Lorenzo, D
对欧洲黑腹果蝇（Drosophila melanogaster）种群X染色体的扫描，揭示了最近在个体基因座上正向选择作用的证据。在这项研究中，我们分析了一个这样的区域，在基因组扫描（位于细胞分裂2C 10 - 2 E1）没有多态性。我们检测到一段60.5 kb的DNA，包括基因ph-d、ph-p、CG 3835、bcn 92、Pgd、wapl和Cyp 4d 1，在欧洲样本中几乎完全没有变异。该区域两侧的基因座在分离位点表现出倾斜的频率谱，强单倍型结构和高水平的连锁不平衡。中性测试表明，这些数据是不可能在中性均衡模型和简单的瓶颈情景。相比之下，新开发的最大似然比检验表明，强选择最近已经对正在调查的区域采取了行动，导致了选择性的横扫。证据表明，这种扫描可能起源于非洲的祖先人口。
A scan of the X chromosome of a European Drosophila melanogaster population revealed evidence for the recent action of positive directional selection at individual loci. In this Study we analyze one such region that showed no polymorphism in the genome scan (located in cytological division 2C10-2E1). We detect a 60.5-kb stretch of DNA encompassing the genes ph-d, ph-p, CG3835, bcn92, Pgd, wapl, and Cyp4d1, which almost completely lacks variation in the European sample. Loci flanking this region show a skewed frequency spectrum at segregating sites, strong haplotype structure, and high levels of linkage disequilibrium. Neutrality tests reveal that these data are unlikely under both the neutral equilibrium model and the simple bottleneck scenarios. In contrast, newly developed maximum-likelihood ratio tests suggest that strong selection has acted recently on the region under investigation, causing a selective sweep. Evidence that this sweep may have originated in an ancestral population in Africa is presented.