The correlation between controlled attenuation parameter and metabolic syndrome and its components in middle-aged and elderly nonalcoholic fatty liver disease patients.
The correlation between controlled attenuation parameter and metabolic syndrome and its components in middle-aged and elderly nonalcoholic fatty liver disease patients.
复制标题
中老年非酒精性脂肪肝患者控制衰减参数与代谢综合征及其成分的相关性
DOI：
10.1097/md.0000000000012931
复制
发表时间：
2018-10
期刊：
影响因子：
1.6
通讯作者：
Yang HJ
中科院分区：
文献类型：
--
作者：
Hu YY;Dong NL;Qu Q;Zhao XF;Yang HJ
摘要 本研究旨在探讨中老年非酒精性脂肪性肝病（NAFLD）患者控制衰减参数（CAP）与代谢综合征（MetS）及其组成成分的相关性。将2016年6月至2017年5月就诊的中老年NAFLD患者作为研究对象，同期将无肝病的中老年患者作为对照。比较不同 CAP 值患者的 MetS 患病率、MetS 成分以及不同数量的 MetS 成分。随着CAP值的增加，MetS的患病率、MetS成分以及MetS成分的不同数量显着增加。 CAP值与MetS、肥胖、高甘油三酯血症、高血压、高血糖、高尿酸血症以及MetS成分数量呈正相关，与低高密度脂蛋白胆固醇血症的患病率呈负相关。中老年 NAFLD 患者中 CAP 值与 MetS 及其成分密切相关。 CAP可能是中老年NAFLD患者发生MetS风险和代谢紊乱严重程度的指标。
Abstract This study aims to investigate the correlation between controlled attenuation parameter (CAP) and metabolic syndrome (MetS) and its components in middle-aged and elderly nonalcoholic fatty liver disease (NAFLD) patients. Middle-aged and elderly patients with NAFLD, who visited our hospital from June 2016 to May 2017, were enrolled as study subjects, whereas middle-aged and elderly patients without liver disease were enrolled as controls in the same period. The prevalence of MetS, MetS components, and the different numbers of MetS components were compared among patients with different CAP values. As the CAP value increased, the prevalence of MetS, MetS components, and the different numbers of MetS components significantly increased. The CAP value was positively correlated with the prevalence of MetS, obesity, hypertriglyceridemia, hypertension, hyperglycemia, hyperuricemia, and the number of MetS components, and was negatively correlated with the prevalence of hypo–high-density-lipoprotein cholesterolemia. CAP values are closely correlated to MetS and its components in middle-aged and elder NAFLD patients. CAP may be an indicator of risk of MetS and the severity of metabolic disorders in middle-aged and elderly NAFLD patients.