Prevalence and risk factors of peripheral artery disease in black Africans with HIV infection: a cross-sectional hospital-based study
Prevalence and risk factors of peripheral artery disease in black Africans with HIV infection: a cross-sectional hospital-based study
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DOI：
10.2147/vhrm.s165960
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发表时间：
2018-01-01
影响因子：
2.9
通讯作者：
Luma, Henry
中科院分区：
文献类型：
--
作者：
Kamdem, Felicite;Mapoure, Yacouba;Luma, Henry
背景：非洲 HIV 感染者中外周动脉疾病 (PAD) 的患病率尚不清楚。本研究的目的是确定杜阿拉总医院 (DGH) HIV 感染患者中 PAD 的患病率和相关危险因素。方法：这是 2015 年 11 月至 2016 年 4 月期间进行的一项横断面描述性和分析性研究。我们招募了年龄 >= 21 岁、诊断为 HIV 感染并在 DGH 接受护理的患者。我们收集了患者的社会人口统计数据和既往病史。我们测量了他们的踝臂指数（ABI）。我们将 PAD 定义为 ABI 0.05)。 PAD 的患病率为 6.9%（95% CI：3.4-12.4），60% 的 PAD 患者有症状。调整年龄、性别和 ARV 后，ARV 治疗具有保护性（aOR：0.18，[95% CI：0.04-0.82]，P=0.034），而 WHO III 期或 IV 期与 PAD 相关（aOR：11.1，[95% CI：2.19-55.92]，P=0.004）。结论：本研究中 PAD 的患病率没有预期的那么高感染艾滋病毒的心血管高危人群。晚期 HIV 疾病与 PAD 相关，而 ARV 具有保护作用。
Background: The prevalence of peripheral artery disease (PAD) is not well known among HIV-infected patients in Africa. The aim of this study was to determine the prevalence and associated risk factors of PAD among HIV-infected patients at the Douala General Hospital (DGH).Methods: This was a cross-sectional descriptive and analytic study between November 2015 and April 2016. We recruited patients aged >= 21 years, diagnosed with HIV infection, and who were receiving care at the DGH. We collected sociodemographic data and past medical history of patients. We measured their ankle-brachial index (ABI). We defined PAD as an ABI 0.05). The prevalence of PAD was 6.9% (95% CI: 3.4-12.4), and 60% of patients with PAD were symptomatic. After adjusting for age, sex and ARV, ARV treatment was protective (aOR: 0.18, [95% CI: 0.04-0.82], P=0.034), while WHO stages III or IV was associated with PAD (aOR: 11.1, [95% CI: 2.19-55.92], P=0.004).Conclusion: The prevalence of PAD was not as high as expected in this group of patients with high cardiovascular risk infected with HIV. Advanced HIV disease was associated with PAD, while ARV was protective.