Review of biomedical Čerenkov luminescence imaging applications.
Review of biomedical Čerenkov luminescence imaging applications.
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DOI：
10.1364/boe.6.003053
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发表时间：
2015-08
影响因子：
3.4
通讯作者：
Kaveh Tanha;A. Pashazadeh;B. Pogue
中科院分区：
文献类型：
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作者：
Kaveh Tanha;A. Pashazadeh;B. Pogue
切伦科夫辐射是一种令人着迷的光学信号，已被用于独特的诊断生物传感和成像，并且在过去五年中其用途显着扩大。切伦科夫发光成像 (CLI) 具有适合利基应用的理想功能，使用专门设计的测量系统报告辐射分布、放射性示踪剂和纳米颗粒浓度，并直接应用于医学评估、内窥镜检查、手术、质量保证和剂量测定等程序。与 PET 和 SPECT 等其他成像工具相比，CLI 具有成本更低、通量更高和成像时间更短的关键优势。 CLI 还可以提供来自放射性同位素和直线加速器辐照的成像和剂量测定信息。组织中光学光子传输的范围相对较短，这意味着直接切伦科夫发光成像仅限于小动物或人类近地表使用。使用切伦科夫激发作为额外的分子探针，现已成为生物传感或放射增敏的关键工具。本综述评估了 CLI 的这些新改进的医学价值和生物学洞察力。
Čerenkov radiation is a fascinating optical signal, which has been exploited for unique diagnostic biological sensing and imaging, with significantly expanded use just in the last half decade. Čerenkov Luminescence Imaging (CLI) has desirable capabilities for niche applications, using specially designed measurement systems that report on radiation distributions, radiotracer and nanoparticle concentrations, and are directly applied to procedures such as medicine assessment, endoscopy, surgery, quality assurance and dosimetry. When compared to the other imaging tools such as PET and SPECT, CLI can have the key advantage of lower cost, higher throughput and lower imaging time. CLI can also provide imaging and dosimetry information from both radioisotopes and linear accelerator irradiation. The relatively short range of optical photon transport in tissue means that direct Čerenkov luminescence imaging is restricted to small animals or near surface human use. Use of Čerenkov-excitation for additional molecular probes, is now emerging as a key tool for biosensing or radiosensitization. This review evaluates these new improvements in CLI for both medical value and biological insight.