Primitive neuroectodermal tumors of the brain in children
Primitive neuroectodermal tumors of the brain in children
复制标题
DOI：
10.1002/1097-0142(197310)32:4
复制
发表时间：
1973-10
期刊：
影响因子：
6.2
通讯作者：
M. Hart;K. Earle
中科院分区：
文献类型：
--
作者：
M. Hart;K. Earle
发生在年轻个体大脑中的主要未分化肿瘤被称为“原始神经外胚层肿瘤”。收集了其中23例具有某些共同特征的病例。大体上呈囊状，压迫邻近脑。显微镜下，它们呈恶性外观，并显示出明显的间充质成分。16例病例显示神经胶质和/或神经元样分化的局灶性证据。提示间质也是肿瘤分化的一个方面。这些肿瘤的生物学行为是恶性的，从症状发作到死亡的平均持续时间为18个月。
Predominantly undifferentiated tumors occurring in the cerebrum of young individuals are referred to as “primitive neuroectodermal tumors.” Twenty‐three of these cases were collected which had certain common features. Grossly they tended to be cystic and compressed adjacent brain. Microscopically they were malignant‐appearing and demonstrated a prominent mesenchymal component. Sixteen cases showed focal evidence of glial and/or neuronal‐appearing differentiation. It is suggested that the mesenchyme is also an aspect of tumor differentiation. The biologic behavior of these tumors was malignant, with an average duration of 18 months from onset of symptoms to death.