Silver(I)-Mediated Phosphorylation/Cyclization Cascade of N-Cyanamide Alkenes for Divergent Access to Quinazolinones and Dihydroisoquinolinones
Silver(I)-Mediated Phosphorylation/Cyclization Cascade of N-Cyanamide Alkenes for Divergent Access to Quinazolinones and Dihydroisoquinolinones
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银 (I) 介导的 N-氰酰胺烯烃的磷酸化/环化级联，用于分别获得喹唑啉酮和二氢异喹啉酮
DOI：
10.1021/acs.orglett.6b00481
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发表时间：
2016
期刊：
影响因子：
5.2
通讯作者：
Sunliang Cui
中科院分区：
文献类型：
--
作者：
Jing Zheng;Yan Zhang;Dahai Wang;Sunliang Cui
本文报道了一种银介导的N-氰胺烯烃的磷酸化/环化自由基级联反应。原位生成的磷自由基加成到N-氰胺烯烃引发级联反应，导致后期环化朝向发散性的4-喹唑啉酮和二氢异喹啉酮。末端和内部的N-氰胺烯烃都适用于该方案，环化反应符合Baldwin规则。
A silver(I)-mediated phosphorylation/cyclization radical cascade ofN-cyanamide alkenes has been developed. The addition of in situ generated phosphorus radical toN-cyanamide alkenes triggers the cascade, resulting in late-stage cyclization toward divergent access to 4-quinazolinones and dihydroisoquinolinones. Both terminal and internalN-cyanamide alkenes are applicable in this protocol, and the cyclizations are consistent with Baldwin’s rule.