Stimulation of tumour cell dissemination by raised temperature (42°C) in rats with transplanted Yoshida tumours
Stimulation of tumour cell dissemination by raised temperature (42°C) in rats with transplanted Yoshida tumours
复制标题
升高温度（42°C）刺激移植吉田肿瘤的大鼠肿瘤细胞传播
作者：
J. Dickson;H. A. Ellis
高温，即温度≥40°C，可能对某些类型的癌细胞具有选择性破坏作用1,2，并且已经进行了通过提高温度治疗人类癌症的零星尝试1 - 3。Rossi-Fanelli及其同事已经证明，在42°C时，多种肿瘤细胞的代谢具有选择性和不可逆的抑制作用，而正常细胞不受影响1,4,5。这些工作人员获得了局部融合术治疗的患者肢体恶性肿瘤的组织学消退。更有效和可控的诱导高温的方法，以及细胞毒性药物的作用可以通过高温增强的报道，进一步激发了人们对这种方法治疗人类恶性肿瘤的兴趣。
HYPERTHERMIA, that is, temperatures ≥40° C, may have a selective destructive effect on some types of cancer cells1,2, and sporadic attempts have been made to treat human cancer by raised temperatures1–3. Rossi-Fanelli and colleagues have demonstrated a selective and irreversible inhibition of metabolism in a variety of tumour cells at 42° C, whereas normal cells were unaffected1,4,5. These workers obtained histological regression of malignant limb tumours in patients treated by regional per fusion with pre warmed blood1. More effective and controlled methods for inducing hyperthermia6, and reports that the action of cytotoxic drugs can be potentiated by hyperthermia7,8, have further stimulated interest in this approach to the treatment of human malignjant tumours.