Functional Imaging Using Diffuse Optical Spectroscopy of Neoadjuvant Chemotherapy Response in Women with Locally Advanced Breast Cancer
Functional Imaging Using Diffuse Optical Spectroscopy of Neoadjuvant Chemotherapy Response in Women with Locally Advanced Breast Cancer
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DOI：
10.1158/1078-0432.ccr-09-1510
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发表时间：
2010-05-01
影响因子：
11.5
通讯作者：
Czarnota, Gregory J.
中科院分区：
文献类型：
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作者：
Soliman, Hany;Gunasekara, Anoma;Czarnota, Gregory J.
目的：用断层近红外漫反射光谱(DOS)功能成像技术测量组织中的脱氧血红蛋白(Hb)、氧合血红蛋白(HBO2)、水分百分比(%Water)和散射力(SP)。在这项研究中，我们评估了接受局部晚期乳腺癌新辅助治疗的患者的肿瘤DOS参数，并描述了它们与临床和病理结果的关系。实验设计：10名患者，每个患者计划接受5次扫描。在治疗前3天、新辅助治疗后1周、4周和8周进行扫描。将肿瘤对应的感兴趣体积加权组织Hb、HBO2、%Water和SP的变化与临床和病理反应进行比较。结果：所有患者的感兴趣肿瘤体积与背景组织相比均有显著差异。5例病理反应良好。四名患者被认为是无反应。一名患者最初对化疗没有反应，但在改变化疗后，有了良好的反应。在5例反应良好的患者中，Hb、HBO2、%Water和SP的平均下降率分别为67.6%(SD=20.8)、58.9%(SD=20.3)、51.2%(SD=28.3)和52.6%(SD=26.4)。4个无应答者的Hb、HBO2、%Water和SP的平均下降率分别为17.7%(SD=9.8)、18.0%(SD=20.8)、15.4%(SD=11.7)和12.6%(SD=10.2)。结论：在4周扫描中，应答者和无应答者除%水外，其余各项功能参数均有显著差异，接近显著水平。因此，DOS可作为肿瘤反应的早期检测指标。临床癌症资源；16(9)；2605-14。(C)2010年AACR。
Purpose: Functional imaging with tomographic near-infrared diffuse optical spectroscopy (DOS) can measure tissue concentration of deoxyhemoglobin (Hb), oxyhemoglobin (HbO2), percent water (%water), and scattering power (SP). In this study, we evaluated tumor DOS parameters and described their relationship to clinical and pathologic outcome in patients undergoing neoadjuvant therapy for locally advanced breast cancer.Experimental Design: Ten patients were enrolled and intended to undergo five scans each. Scans were taken up to 3 days before treatment and at 1, 4, and 8 weeks after neoadjuvant treatment before surgery. Changes in volume of interest weighted tissue Hb, HbO2, %water, and SP corresponding to the tumor were compared with clinical and pathologic response.Results: All patients' tumor volumes of interest were significantly different compared with background tissue for all parameters. Five patients had a good pathologic response. Four patients were considered nonresponders. One patient initially did not respond to chemotherapy but, after a change in chemotherapy, had a good response. In the five patients with a good response, the mean drop in Hb, HbO2, %water, and SP from baseline to the 4-week scan was 67.6% (SD = 20.8), 58.9% (SD = 20.3), 51.2% (SD = 28.3), and 52.6% (SD = 26.4), respectively. In contrast, the four nonresponders had a mean drop of 17.7% (SD = 9.8), 18.0% (SD = 20.8), 15.4% (SD = 11.7), and 12.6% (SD = 10.2) for Hb, HbO2, %water, and SP, respectively.Conclusions: Responders and nonresponders were significantly different for all functional parameters at the 4-week scan, except for %water, which approached significance. Thus, DOS could be used as an early detector of tumor response. Clin Cancer Res; 16(9); 2605-14. (C) 2010 AACR.