ADAPTATION OF FAT-CELLS TO EXERCISE - RESPONSE OF GLUCOSE-UPTAKE AND OXIDATION TO INSULIN
ADAPTATION OF FAT-CELLS TO EXERCISE - RESPONSE OF GLUCOSE-UPTAKE AND OXIDATION TO INSULIN
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DOI：
10.1152/jappl.1981.51.6.1500
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发表时间：
1981-01-01
影响因子：
3.3
通讯作者：
HOLLOSZY, JO
中科院分区：
文献类型：
--
作者：
CRAIG, BW;HAMMONS, GT;HOLLOSZY, JO
研究了运动训练是否会改变脂肪细胞中葡萄糖摄取和氧化对胰岛素的敏感性和反应性。雌性大鼠游泳6小时/天，5天/周，连续12周。游泳运动员的脂肪细胞比同龄、体重相近的久坐不动的对照组要小。由于胰岛素受体数量的增加，更多的胰岛素被训练鼠的脂肪细胞特异性结合。在所有胰岛素浓度下，训练大鼠的脂肪细胞中2-脱氧葡萄糖的摄取率和葡萄糖氧化率都高于静止大鼠。最大胰岛素刺激导致训练大鼠的糖摄取和氧化率比不运动大鼠的脂肪细胞高约6倍。这种对胰岛素的更大的反应性不能用胰岛素结合的增加来解释，而似乎是在胰岛素与其受体结合之后的一个步骤中由适应介导的。经过运动训练的动物的脂肪细胞似乎适应了能量储存的快速补充。
Whether exercise training alters the sensitivity and responsiveness to insulin of glucose uptake and oxidation in fat cells was examined. Female rats were exercised by swimming 6 h/day, 5 days/wk for 12 wk. The swimmer''s fat cells were smaller than those of sedentary controls of the same age and similar body weight. A larger amount of insulin was specifically bound by fat cells of the trained rats because of an increase in the number of insulin receptors. The rates of 2-deoxyglucose uptake and of glucose oxidation were higher in fat cells of trained rats compared with sedentary rats at all insulin concentrations. A maximal insulin stimulus resulted in rates of sugar uptake and oxidation that were about six-fold higher in trained rats than in sedentary rats'' fat cells. This greater responsiveness to insulin could not be explained by the increase in insulin binding but appears to be mediated by adaptation(s) at a step(s) beyond the binding of insulin to its receptors. Fat cells of exercise-trained animals seem to be adapted for rapid replenishment of energy stores.