TJIPANAZOLES, NEW ANTIFUNGAL AGENTS FROM THE BLUE-GREEN-ALGA TOLYPOTHRIX-TJIPANASENSIS
TJIPANAZOLES, NEW ANTIFUNGAL AGENTS FROM THE BLUE-GREEN-ALGA TOLYPOTHRIX-TJIPANASENSIS
复制标题
DOI：
10.1016/s0040-4020(01)81932-3
复制
发表时间：
1991-09-09
期刊：
影响因子：
2.1
通讯作者：
PATTERSON, GML
中科院分区：
文献类型：
--
作者：
BONJOUKLIAN, R;SMITKA, TA;PATTERSON, GML
利用生物活性定向分离技术，分离得到了15个新的吲哚[2,3-a]咔唑n -苷类化合物，分别为：t1， A2， B, C1, C2, C3, C4， D， E, F1, F2, G1, G2， I和j。通过物理方法、化学降解和合成等方法确定了这些生物碱的结构。Tjipanazole J是唯一具有先前描述的吲哚[2,3-a]咔唑的吡咯[3,4-c]环的化合物。
Bioactivity-directed isolation of the extract of the cyanophyte Tolypothrix tjipanasensis has led to the isolation of fifteen new N-glycosides of indolo[2,3-a]carbazoles designated tjipanazoles A1, A2, B, C1, C2, C3, C4, D, E, F1, F2, G1, G2, I and J. The structures of the alkaloids were determined by physical methods, chemical degradation and synthesis. Tjipanazole J is the only compound having the pyrrolo[3,4-c] ring of previously described indolo[2,3-a]carbazoles.