Diagnostic potential of polarized surface enhanced Raman spectroscopy technology for colorectal cancer detection
Diagnostic potential of polarized surface enhanced Raman spectroscopy technology for colorectal cancer detection
复制标题
偏振表面增强拉曼光谱技术在结直肠癌检测中的诊断潜力
DOI：
10.1364/oe.24.002222
复制
发表时间：
2016-02-08
期刊：
影响因子：
3.8
通讯作者：
Chen, Rong
中科院分区：
文献类型：
--
作者：
Lin, Duo;Huang, Hao;Chen, Rong
本研究的目的是开发一种基于偏振表面增强拉曼光谱（SERS）技术的更强大的血液分析方法，用于无创且灵敏的结直肠癌（CRC）检测。首次探讨了不同偏振散射信号（非偏振、平行偏振和垂直偏振）对血清SERS的效率。结果表明，偏振 SERS 对于探索癌症组和正常组之间的独特光谱差异更加敏感。与传统的 SERS 技术相比，使用偏振 SERS 与 PCA-LDA 集成对两个血清组进行分类可以实现高达 91.6% 的诊断准确性。这项探索性研究表明，基于偏振 SERS 技术与 PCA-LDA 相结合的纳米生物传感器为血液 SERS 分析提供了一种新策略，并具有作为 CRC 筛查的临床补充的潜力。 (C) 2015年美国光学学会
The purpose of this study was to develop a more powerful blood analysis method based on polarized surface enhanced Raman spectroscopy (SERS) technology for non-invasive and sensitive colorectal cancer (CRC) detection. The efficiency of different polarized scattering signals (non-polarization, parallel polarization and perpendicular polarization) on blood serum SERS was explored for the first time. Results demonstrated that polarized SERS was more sensitive to explore distinctive spectral differences between cancer and normal groups. And higher diagnostic accuracy of 91.6% could be achieved using polarized SERS integrated with PCA-LDA for classification of the two serum groups in comparison to conventional SERS technology. This exploratory study demonstrated that the nanobiosensor based on polarized SERS technique in conjunction with PCA-LDA provided a novel strategy for blood SERS analysis, and had the potential as a clinical complement for CRC screening. (C) 2015 Optical Society of America