Skeletal muscle mass and muscle strength in relation to lower-extremity performance in elder men and women
Skeletal muscle mass and muscle strength in relation to lower-extremity performance in elder men and women
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DOI：
10.1111/j.1532-5415.2000.tb04694.x
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发表时间：
2000-04-01
影响因子：
6.3
通讯作者：
Bouter, LM
中科院分区：
文献类型：
--
作者：
Visser, M;Deeg, DJH;Bouter, LM
目的：低肌肉力量与较差的身体功能有关，但有限的经验证据可证明肌肉质量和身体功能之间的关系。设计：一项横断面的、以人群为基础的研究。参与者：449名年龄在65岁及以上、居住在阿姆斯特丹及其周边地区的男性和女性，参加第二次检查（1995-1996）的纵向老化研究阿姆斯特丹。测量：腿部骨骼肌质量测量使用双能X-rap吸收测定法（DXA）。握力被用作肌肉力量的指标。定时功能性能测试，包括步行和重复椅子站立，被用来评估LEP.Results：调整身高和年龄后，腿部肌肉质量与男性LEP呈正相关（回归系数0.178 [95%置信区间0.013-0.343]，P = 0.035）。在女性中观察到负相关，在对体重指数（BMI）进行额外调整后变为正相关（0.202 [-0.001-0.405]，P = 0.052）。男性和女性的握力与LEP呈正相关。在对行为、生理和心理变量进行额外调整后，腿部肌肉质量和LEP之间的关联消失，而男性握力仍然与LEP独立相关（0.079 [0.042-0.116]，P = 0.0001），女性有这种趋势（0.046 [-0.009-0.101]，P = 0.11）。结果是相似的，当四分位数的腿部肌肉质量或握力were used.CONCLUSIONS：这些结果表明，低肌肉力量，但不是低肌肉质量，与身体功能差的老年男性和女性。然而，需要前瞻性研究来调查肌肉质量损失与身体功能之间的关联。
OBJECTIVE: Low muscle strength is associated with poorer physical function, but limited empirical evidence is available to prove the relationship between muscle mass and physical function. We tested the hypothesis that persons with lower muscle mass or muscle strength have poorer lower-extremity performance (LEP).DESIGN: A cross-sectional, population-based study.PARTICIPANTS: A cohort of 449 men and women aged 65 years and older living in Amsterdam and its surroundings participating in the second examination (1995-1996) of the Longitudinal Aging Study Amsterdam.MEASUREMENTS: Leg skeletal muscle mass was measured using dual-energy X-rap absorptiometry (DXA). Grip strength was used as an indicator of muscle strength. Timed functional performance tests, including walking and repeated chair stands, were used to assess LEP.RESULTS: After adjustment for body height and age, leg muscle mass was positively associated with LEP in men (regression coefficient 0.178 [95% confidence interval 0.013-0.343], P =.035). In women an inverse association was observed, which became positive after additional adjustment for body mass index (BMI) (0.202 [-0.001-0.405], P = .052). Grip strength was positively associated with LEP in men and women. After additional adjustment for behavioral, physiological, and psychological variables, the associations between leg muscle mass and LEP disappeared, whereas grip strength remained to be independently associated with LEP in men (0.079 [0.042-0.116], P = .0001), with a tendency in women (0.046 [-0.009-0.101], P = .11). Results were similar when quartiles of leg muscle mass or grip strength were used.CONCLUSIONS: These results suggest that low muscle strength, but not low muscle mass, is associated with poor physical function in older men and women. However, prospective studies are needed to investigate the association between loss of muscle mass and physical function.