Vancomycin population pharmacokinetics and dosing recommendations in haematologic malignancy with augmented renal clearance children
Vancomycin population pharmacokinetics and dosing recommendations in haematologic malignancy with augmented renal clearance children
复制标题
万古霉素在血液系统恶性肿瘤肾清除率增高儿童中的群体药代动力学和剂量建议
DOI：
10.1111/jcpt.13206
复制
发表时间：
2020-06-18
影响因子：
2
通讯作者：
Liu, Tao-Tao
中科院分区：
文献类型：
--
作者：
Lv, Chun-Le;Lu, Jie-Jiu;Liu, Tao-Tao
肾清除率增加（ARC）的特征是肾清除率增加，导致万古霉素暴露不足和治疗失败。在血液系统恶性肿瘤患者中，确定最佳万古霉素剂量至关重要，因为危及生命的细菌感染风险高，清除率增加。本研究的目的是描述肾清除率增加的血液系统恶性肿瘤儿童中万古霉素的药代动力学参数，并确定适当的给药方案，以达到AUC 0 - 24 h/MIC ≥400。
Augmented renal clearance (ARC) is characterized by enhanced renal clearance, which leads to insufficient vancomycin exposure and treatment failure. In haematologic malignancy patients, determination of optimal vancomycin dosage is essential because of high stake of life‐threatening bacterial infection and increased clearance. The aim of this study was to describe vancomycin pharmacokinetic parameters in haematologic malignancy with augmented renal clearance children and define the appropriate dosing regimen to achieve an AUC0‐24h/MIC ≥400.