Reduced serum Gc-globulin concentrations in patients with fulminant hepatic failure: Association with multiple organ failure
Reduced serum Gc-globulin concentrations in patients with fulminant hepatic failure: Association with multiple organ failure
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DOI：
10.1097/00003246-199708000-00025
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发表时间：
1997-08-01
影响因子：
8.8
通讯作者：
Tygstrup, N
中科院分区：
文献类型：
--
作者：
Schiodt, FV;Ott, P;Tygstrup, N
目的：评价暴发性肝衰竭患者入院时血清肌动蛋白清除剂、GC-球蛋白浓度与随后发生多器官功能衰竭之间的关系。设计：回顾性研究。设置：肝病重症监护室。患者：79例3级或4级肝性脑病患者。干预：无。测量和主要结果：测定入院时血清总的和非肌动蛋白复合（游离）的Gc-球蛋白浓度，记录每例患者心血管衰竭、肾衰竭、肺衰竭、颅内高压和感染的发展。与正常对照组相比，患者的总Gc-球蛋白和游离Gc-球蛋白值均显著降低，随后发生心血管衰竭的患者Gc-球蛋白值显著降低（p
Objective: To evaluate the association between admission serum concentrations of the actin-scavenger, Gc-globulin, and the subsequent development of multiple organ failure in patients with fulminant hepatic failure.Design: Retrospective study.Setting: A hepatologic intensive care unit.Patients: Seventy-nine patients with hepatic encephalopathy grade 3 or 4.Interventions: None.Measurements and Main Results: Serum admission concentrations of both total and nonactin-complexed (free) Gc-globulin were determined, The development of cardiovascular failure, renal failure, pulmonary failure, intracranial hypertension, and infections were recorded in each patient. Both total and free Gc-globulin values were significantly lower in the patients, compared with normal controls, The Gc-globulin values were significantly reduced in patients who subsequently developed cardiovascular failure (p