Predictive Milling of Pharmaceutical Materials Using Nanoindentation of Single Crystals
Predictive Milling of Pharmaceutical Materials Using Nanoindentation of Single Crystals
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DOI：
10.1021/op0300241
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发表时间：
2004-05
影响因子：
3.4
通讯作者：
L. J. Taylor;D. Papadopoulos;P. Dunn;A. Bentham;N. Dawson;John C. Mitchell-;M. Snowden
中科院分区：
文献类型：
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作者：
L. J. Taylor;D. Papadopoulos;P. Dunn;A. Bentham;N. Dawson;John C. Mitchell-;M. Snowden
五种药物材料，包括两种盐和三种中性化合物，已经在单晶尺度上进行了纳米压痕分析。使用纳米压痕实验来计算五种材料中的每一种的脆性指数。将这些结果与在中试规模磨机上获得的尺寸减小进行比较。单晶和大型中试规模的结果之间有很好的相关性，获得了研究的材料范围。
Five pharmaceutical materials, including two salts and three neutral compounds, have been subjected to nanoindentation analysis on a single-crystal scale. The nanoindentation experiments were used to calculate a brittleness index for each of the five materials. These results were compared to the size reductions that were obtained on a pilot-plant scale mill. A good correlation between single crystal and large pilot-plant scale results was obtained for the range of materials studied.