Bone loss is a physiological cost of reproduction in white-footed mice (Peromyscus leucopus)
Bone loss is a physiological cost of reproduction in white-footed mice (Peromyscus leucopus)
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骨质流失是白足小鼠（Peromyscus leucopus）繁殖的生理成本
DOI：
10.1016/j.mambio.2013.09.003
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发表时间：
2014
影响因子：
1.6
通讯作者：
W. Hood
中科院分区：
文献类型：
--
作者：
Christina M Schmidt;W. Hood
对后代生产的投资往往需要调动内源性资源，这一战略可能会对产妇的状况产生负面影响。在哺乳动物中，生长中的后代的骨骼骨化需要母亲投入大量的钙，而骨丢失在几个物种中被描述为支持这一需求的一种手段。尽管骨质流失会对母亲产生不利影响，但它在生殖权衡中的潜在作用尚未得到解决。利用白足小鼠(Permyscus Leucopus)，我们测试了饮食中钙的有效性对生殖期间母体骨骼状况的影响，以评估钙的有效性是否会在母体骨骼状况和子代生产之间进行权衡。我们给小鼠提供低钙或标准饮食，并监测生殖输出以及整个生殖过程中骨密度和骨吸收(通过血清中吡啶酚交联物浓度)的变化。低钙摄入不会影响繁殖性能。与食用标准饲料的生殖雌性小鼠和食用低钙饮食的非生殖雌性小鼠相比，低钙饮食的生殖雌性小鼠的骨密度显著降低，但骨吸收活性没有差异。我们的结果表明，当饮食中的钙受到限制时，白足小鼠会以骨骼状况为代价进行繁殖，这可能是通过限制相对于吸收的骨矿物质积累来实现的。
Investment in offspring production often requires the mobilization of endogenous resources, a strategy that may negatively impact maternal condition. In mammals, skeletal ossification in growing offspring requires a large investment of calcium by mothers, and bone loss has been described in several species as a means of supporting this demand. Although bone loss can have adverse effects on the mother, its potential role in a reproductive trade-off has not been addressed. Using white-footed mice (Peromyscus leucopus), we tested the effect of dietary calcium availability on maternal skeletal condition during reproduction to assess if calcium availability drives a trade-off between maternal skeletal condition and offspring production. We provided mice with a low-calcium or standard diet and monitored reproductive output along with changes in bone mineral density and bone resorption (via serum concentrations of pyridinoline cross-links) throughout reproduction. Reproductive performance was not impaired by low calcium intake. Reproductive females on the low-calcium diet showed a significant reduction in bone mineral density relative to reproductive females consuming the standard diet and non-reproductive mice consuming the low-calcium diet, but no difference in bone resorptive activity. Our results suggest that when dietary calcium is limited white-footed mice reproduce at the expense of their skeletal condition, and may do so by limiting bone mineral accretion relative to resorption.
哺乳仔鼠数量和膳食钙对哺乳大鼠股骨骨矿物质含量和力学性能的影响。
DOI：
--
发表时间：
1988
期刊：
Bone and mineral
影响因子：
--
作者：
Peng,TC;Garner,SC;Kusy,RP;Hirsch,PF
通讯作者：
Hirsch,PF
影响因子：
20.3
作者：
C. Kovacs;H. Kronenberg
通讯作者：
C. Kovacs;H. Kronenberg
影响因子：
4.2
作者：
BROMMAGE, R
通讯作者：
BROMMAGE, R