miRNA-221 of exosomes originating from bone marrow mesenchymal stem cells promotes oncogenic activity in gastric cancer.
miRNA-221 of exosomes originating from bone marrow mesenchymal stem cells promotes oncogenic activity in gastric cancer.
复制标题
源自骨髓间充质干细胞的外泌体的 miRNA-221 促进胃癌的致癌活性
DOI：
10.2147/ott.s143315
复制
发表时间：
2017
影响因子：
4
通讯作者：
Zuo C
中科院分区：
文献类型：
--
作者：
Ma M;Chen S;Liu Z;Xie H;Deng H;Shang S;Wang X;Xia M;Zuo C
在世界范围内，胃癌是消化系统最致命的恶性肿瘤之一。此外，癌细胞内的外切体的microRNAs(MiRNAs)已被确定可诱导炎症条件，从而加速肿瘤的生长和转移。有趣的是，骨髓间充质干细胞(BM-MSCs)在调节免疫抑制、肿瘤侵袭和转移中的致癌作用被发现部分是通过分泌外切体来调节的。本文认为外周血中miRNA-221(miR-221)的高表达与胃癌的临床预后呈正相关，尤其是在肿瘤、淋巴结和转移分期方面。因此，miR-221在外周血外周血中的表达可能是胃癌的一个重要检测指标。转染miR-221模拟物的BM-MSCs来源的外体显著促进了BGC-823和SGC-7901细胞的增殖、迁移、侵袭和与基质的黏附。综上所述，从转miR-221寡核苷酸的BM-MSCs中提取的外切体可以作为高效的纳米载体，提供足够的miR-221寡核苷酸，有效地影响肿瘤微环境和肿瘤的侵袭性。值得注意的是，在外切体中使用具有良好抑制效果的miR-221抑制剂为GC在未来的临床医学中提供了治疗潜力。
Worldwide, gastric cancer (GC) is one of the deadliest malignant tumors of the digestive system. Moreover, microRNAs (miRNAs) of exosomes harbored within cancer cells have been determined to induce inflammatory conditions that accelerate tumor growth and metastasis. Interestingly, the oncogenic role of bone marrow mesenchymal stem cells (BM-MSCs) in the modulation of immunosuppression, tumor invasion, and metastasis was discovered to be partly mediated through the secretion of exosomes. In this article, high expression of miRNA-221 (miR-221) in exosomes of the peripheral blood was determined to be positively correlated with the poor clinical prognosis of GC, especially with respect to tumor, node, and metastases stage. Therefore, the expression of miR-221 in exosomes of the peripheral blood may be an important detection index for GC. Proliferation, migration, invasion, and adhesion to the matrix of GC BGC-823 and SGC-7901 cells were significantly enhanced by exosomes that originated from BM-MSCs that were transfected with miR-221 mimics. In conclusion, extracted exosomes from BM-MSCs transfected with miR-221 oligonucleotides can act as high-efficiency nanocarriers, which can provide sufficient miR-221 oligonucleotides to influence the tumor microenvironment and tumor aggressiveness effectively. Notably, the use of a miR-221 inhibitor with an excellent restraining effect in exosomes provides therapeutic potential for GC in future clinical medicine.