The platelets as foci in the coagulation of the blood.
The platelets as foci in the coagulation of the blood.
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血小板作为血液凝固的焦点。
DOI：
10.1152/ajplegacy.1949.158.1.84
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发表时间：
1948
期刊：
影响因子：
--
通讯作者：
D. Mathieson
中科院分区：
文献类型：
--
作者：
F. D. Mann;M. Hurn;D. Mathieson
许多形态学观察，特别是Fonio和Schwendener（I）的观察，表明血小板在血液凝固中具有重要的，可能是起始作用。为了充分延缓凝血过程以允许准确观察，Fonio和Schwendener使用了各种抗凝剂和低温。另一方面，托坎廷斯（2）研究了血友病血浆的凝血，并观察到纤维蛋白丝的形成与血小板无关。尽管血小板不含可观量的凝血酶原，但最近的工作（3-6）表明，有一种与血小板相关的物质促进凝血酶原转化为凝血酶。正常人血浆在涂有硅酮的玻璃中凝固得足够慢，以允许观察该过程。我们要报告的正是这些观察结果。我们还比较了血小板和血浆中所谓的“凝血酶原转换因子”的含量，并将包括我们的比较结果。
Numerous morphologic observations, especially those of Fonio and Schwendener (I), suggest that the platelets have an important, possibly an initiating role, in the coagulation of blood. In order to retard the clotting process enough to permit accurate observation, Fonio and Schwendener employed various anticoagulants and low temperatures. Tocantins (2), on the other hand, studied the clotting of hemophilic plasma and observed that fibrin threads formed independent of the platelets. Although platelets do not contain an appreciable amount of prothrombin, recent work (3-6) indicates that there is a material associated with them which facilitates the conversion of prothrombin to thrombin. Normal human plasma clots slowly enough in silicone-coated glass to permit observation of the process. It is such observations which we wish to report. We also compared platelets to plasma in content of what might be termed ‘prothrombin conversion factors’ and shall include the results of our comparison.