Lipase-catalyzed domino kinetic resolution of α-hydroxynitrones/intramolecular 1,3-dipolar cycloaddition:: a concise asymmetric total synthesis of (-)-rosmarinecine
Lipase-catalyzed domino kinetic resolution of α-hydroxynitrones/intramolecular 1,3-dipolar cycloaddition:: a concise asymmetric total synthesis of (-)-rosmarinecine
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DOI：
10.1039/b419426h
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发表时间：
2005-01-01
影响因子：
4.9
通讯作者：
Kita, Y
中科院分区：
文献类型：
--
作者：
Akai, S;Tanimoto, K;Kita, Y
开发标题多米诺反应，直接从外消旋 α-羟基硝酮（2 和 6）中生成四氢呋喃并[3,4-c]异恶唑衍生物（5 和 9），其 ee ≥ 90%，用于 (-)-迷迭香碱 10 的简明不对称全合成。
The title domino reactions were developed to directly provide tetrahydrofuro[3,4-c]isoxazole derivatives (5 and 9) in >= 90% ee from racemic alpha-hydroxynitrones (2 and 6), which were used in the concise asymmetric total synthesis of (-)-rosmarinecine 10.