Risk of lymphatic or haematopoietic cancer mortality with occupational exposure to animals or the public
Risk of lymphatic or haematopoietic cancer mortality with occupational exposure to animals or the public
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DOI：
10.1136/oem.2005.021550
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发表时间：
2005-10-01
影响因子：
4.9
通讯作者：
De Roos, AJ
中科院分区：
文献类型：
--
作者：
Svec, MA;Ward, MH;De Roos, AJ
背景资料：职业性暴露于动物或公众可能导致接触传染性病原体，这可能在淋巴造血（LH）cancers.Aims的病因学中发挥作用：进行一项基于人群的病例对照研究，对1984年至1998年美国24个州的死亡证明数据进行研究，以评估与职业性暴露于动物或公众相关的LH肿瘤死亡风险。病例被选择为非霍奇金淋巴瘤的潜在死亡原因（NHL，n = 72 589），霍奇金病（HD，n = 5479），多发性骨髓瘤（n = 35 857），或白血病（n = 68 598）; 912 615名对照者从所有剩余的死亡者中随机选择，频率与年龄、性别、种族和地理区域相匹配。职业暴露于动物与所有四种LH癌症的死亡率风险适度增加相关;这些关联因地区而异。公众职业暴露与LH癌结局风险增加仅可忽略不计。涉及动物暴露的职业主要是农业，与畜牧业就业相关的风险超过了相应的风险与农作物产业的所有结果，除了HD。结论：NHL，HD，多发性骨髓瘤和白血病的风险增加与涉及动物暴露的职业。风险的区域差异意味着风险可能与接触特定的牲畜或耕作方法有关。然而，这些关联可能会被其他与农业相关的暴露（例如农药）所混淆。由于使用死亡证明对职业进行分类可能会导致病因相关时间段内的错误分类，因此应在具有终身职业详细信息的研究中进一步探讨这些假设。
Background: Occupational exposure to animals or the public could result in exposure to infectious agents, which may play a role in the aetiology of lymphohaematopoietic (LH) cancers.Aims: To conduct a population based, case-control study of death certificate data from 1984 to 1998 in 24 US states in order to evaluate the risk of mortality from LH neoplasms associated with occupational exposure to animals or the public.Methods: Cases were selected as those with an underlying cause of death of non-Hodgkin's lymphoma (NHL, n = 72 589), Hodgkin's disease (HD, n = 5479), multiple myeloma ( n = 35 857), or leukaemia ( n = 68 598); 912 615 controls were randomly selected from all remaining deaths, frequency matched on age, sex, race, and geographic region.Results: Occupational exposure to animals was associated with modest increased risks of mortality from all four LH cancers; these associations varied by region. Occupational exposure to the public was associated with only negligible increased risk with LH cancer outcomes. Occupations involving animal exposure were predominantly agricultural, and the risks associated with employment in the livestock industry exceeded the corresponding risks associated with the crop industry for all outcomes except HD.Conclusions: Increased risks of NHL, HD, multiple myeloma, and leukaemia were associated with occupations that involved animal exposure. Regional differences in risk imply that the risks may be associated with exposure to specific livestock or farming practices. However, these associations may be confounded by other farming related exposures, such as pesticides. Because the use of death certificates to classify occupation may result in misclassification during aetiologically relevant time periods, these hypotheses should be further explored in studies with detailed information on lifetime occupation.