Altered hippocampal morphology in unmedicated patients with major depressive illness.
Altered hippocampal morphology in unmedicated patients with major depressive illness.
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DOI：
10.1042/an20090026
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发表时间：
2009-11-10
期刊：
影响因子：
4.7
通讯作者：
Soares JC
中科院分区：
文献类型：
--
作者：
Bearden CE;Thompson PM;Avedissian C;Klunder AD;Nicoletti M;Dierschke N;Brambilla P;Soares JC
尽管有越来越多的证据表明，重度抑郁症与记忆障碍和海马病理学有关，但研究结果在不同研究中差异很大，目前尚不清楚这些变化是否具有区域特异性。在本研究中，我们获得了31例未经药物治疗的MDD患者（重度抑郁症;平均年龄39.2±11.9岁; 77%为女性）和31例人口统计学上可比的对照组的脑MRI（磁共振图像）。建立三维参数网格模型，以检查海马形态的局部改变。虽然两组之间的总体体积没有差异，但统计学映射结果显示，在MDD患者中，更严重的抑郁症状与更大的左海马萎缩相关，特别是在CA 1（角氨1）子字段和下托。然而，既往非典型抗精神病药物治疗与左侧海马体积增大的趋势相关。我们的研究结果表明，疾病的严重程度对海马大小的影响，以及过去的非典型抗精神病药物治疗史的可能影响，这可能反映了长期的神经保护作用。这种可能性有待于纵向研究的证实。
Despite converging evidence that major depressive illness is associated with both memory impairment and hippocampal pathology, findings vary widely across studies and it is not known whether these changes are regionally specific. In the present study we acquired brain MRIs (magnetic resonance images) from 31 unmedicated patients with MDD (major depressive disorder; mean age 39.2±11.9 years; 77% female) and 31 demographically comparable controls. Three-dimensional parametric mesh models were created to examine localized alterations of hippocampal morphology. Although global volumes did not differ between groups, statistical mapping results revealed that in MDD patients, more severe depressive symptoms were associated with greater left hippocampal atrophy, particularly in CA1 (cornu ammonis 1) subfields and the subiculum. However, previous treatment with atypical antipsychotics was associated with a trend towards larger left hippocampal volume. Our findings suggest effects of illness severity on hippocampal size, as well as a possible effect of past history of atypical antipsychotic treatment, which may reflect prolonged neuroprotective effects. This possibility awaits confirmation in longitudinal studies.