Allium victorialis L. Extracts Promote Activity of FXR to Ameliorate Alcoholic Liver Disease: Targeting Liver Lipid Deposition and Inflammation.
Allium victorialis L. Extracts Promote Activity of FXR to Ameliorate Alcoholic Liver Disease: Targeting Liver Lipid Deposition and Inflammation.
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胜利葱提取物促进 FXR 活性改善酒精性肝病：针对肝脏脂质沉积和炎症
DOI：
10.3389/fphar.2021.738689
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发表时间：
2021
影响因子：
5.6
通讯作者：
Wu YL
中科院分区：
文献类型：
--
作者：
Cui ZY;Han X;Jiang YC;Dou JY;Yao KC;Hu ZH;Yuan MH;Bao XX;Zhou MJ;Liu Y;Lian LH;Zhang X;Nan JX;Wu YL
Allium victorialis L. （AVL）是明代《本草纲目》中记载的传统药用植物。一般用于止血、镇痛、抗炎、抗氧化，并有特别促进保肝的作用。近年来，由于其特殊的营养和药用价值，越来越受到人们的重视。本研究探讨AVL抗酒精性肝病（ALD）的作用及其潜在机制。C57BL/6小鼠饲喂含5%乙醇的Lieber-DeCarli液体饲粮加单次乙醇灌胃（5 g/kg），随后给予AVL或水飞蓟素。用乙醇刺激AML12细胞，并用AVL孵育。AVL显著降低血清转氨酶和肝脏甘油三酯，减轻乙醇引起的组织病理改变。AVL显著抑制SREBP1及其靶基因，调节脂素1/2，升高PPARα及其靶基因，降低乙醇引起的PPARγ表达。此外，与EtOH组相比，AVL显著增强了FXR、LXRs、Sirt1和AMPK的表达。AVL还能抑制炎症因子、NLRP3、F4/80和MPO、巨噬细胞和中性粒细胞标志物。在体外，AVL显著降低脂滴、脂质代谢酶和依赖于FXR激活的炎症因子。AVL可通过激活FXR改善酒精性脂肪性肝炎、脂质沉积和ALD炎症。
Allium victorialis L. (AVL) is a traditional medicinal plant recorded in the Compendium of Materia Medica (the Ming Dynasty). In general, it is used for hemostasis, analgesia, anti-inflammation, antioxidation, and to especially facilitate hepatoprotective effect. In recent years, it has received more and more attention due to its special nutritional and medicinal value. The present study investigates the effect and potential mechanism of AVL against alcoholic liver disease (ALD). C57BL/6 mice were fed Lieber–DeCarli liquid diet containing 5% ethanol plus a single ethanol gavage (5 g/kg), and followed up with the administration of AVL or silymarin. AML12 cells were stimulated with ethanol and incubated with AVL. AVL significantly reduced serum transaminase and triglycerides in the liver and attenuated histopathological changes caused by ethanol. AVL significantly inhibited SREBP1 and its target genes, regulated lipin 1/2, increased PPARα and its target genes, and decreased PPARγ expression caused by ethanol. In addition, AVL significantly enhanced FXR, LXRs, Sirt1, and AMPK expressions compared with the EtOH group. AVL also inhibited inflammatory factors, NLRP3, and F4/80 and MPO, macrophage and neutrophil markers. In vitro, AVL significantly reduced lipid droplets, lipid metabolism enzymes, and inflammatory factors depending on FXR activation. AVL could ameliorate alcoholic steatohepatitis, lipid deposition and inflammation in ALD by targeting FXR activation.
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DOI：
10.1016/j.bbrc.2008.06.006
发表时间：
2008-08-22
影响因子：
3.1
作者：
Lieber, Charles S.;Leo, Maria Anna;DeCarli, Leonore M.
通讯作者：
DeCarli, Leonore M.
影响因子：
2.8
作者：
Bi, Lijuan;Jiang, Zhian;Zhou, Junying
通讯作者：
Zhou, Junying
影响因子：
4.3
作者：
Liu, Jinyao
通讯作者：
Liu, Jinyao
影响因子：
4.6
作者：
Li X;Lian F;Liu C;Hu KQ;Wang XD
通讯作者：
Wang XD
DOI：
10.1111/j.1530-0277.2007.00407.x
发表时间：
2007-07-01
影响因子：
3.2
作者：
Esfandiari, Farah;You, Min;Halsted, Charles H.
通讯作者：
Halsted, Charles H.