ANTIMICROBIAL ACTIVITY OF PROTOANEMONIN, A LACTONE FROM RANUNCULACEOUS PLANTS
ANTIMICROBIAL ACTIVITY OF PROTOANEMONIN, A LACTONE FROM RANUNCULACEOUS PLANTS
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DOI：
10.1007/bf00437648
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发表时间：
1987-06-01
期刊：
影响因子：
5.5
通讯作者：
MARES, D
中科院分区：
文献类型：
--
作者：
MARES, D
原白头翁素是毛茛的一种成分，对皮肤癣菌和酵母菌的抗真菌作用进行了试验。最小抑制浓度范围为2.0 - 7.5 × 10 - 6。10-4 M和最小致死浓度从3.8 × 104 μ g/ml到100 × 104 μ g/ml。10-4 M至> 1.0 ×10-3 M.最敏感的皮肤真菌测试是絮状表皮癣菌，和最敏感的酵母菌红酵母。同时还研究了不同培养基和光照条件对红酵母对原白头翁素敏感性的影响。原白头翁素和其他细胞毒性不饱和内酯之间的结构相似性，以及抗真菌作用的氨基酸半胱氨酸的逆转表明了一种可能的作用机制。
Protoanemonin, a component of Ranunculus bulbosus, was tested as an antifungal agent on selected strains of dermatophytes and yeasts. The minimum inhibitory concentrations ranged from 2.0 to 7.5 .times. 10-4 M and the minimum lethal concentrations from 3.8 .times. 10-4 M to > 1.0 .times. 10-3 M. The most sensitive dermatophyte tested was Epidermophyton floccosum, and the most sensitive yeast Rhodotorula glutinis. The effects of different culture media and of light on the sensitivity of Rhodotorula glutinis to protoanemonin were also tested. Structural analogies between protoanemonin and other cytotoxic unsaturated lactones, and the reversal by the amino acid cysteine of the antifungal action suggest a possible mechanism of action.