The Anti-Inflammatory Effects of Statins on Coronary Artery Disease: An Updated Review of the Literature.
The Anti-Inflammatory Effects of Statins on Coronary Artery Disease: An Updated Review of the Literature.
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DOI：
10.2174/1573403x13666170426104611
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发表时间：
2017
影响因子：
1.9
通讯作者：
Troupis T
中科院分区：
文献类型：
--
作者：
Diamantis E;Kyriakos G;Quiles-Sanchez LV;Farmaki P;Troupis T
他汀类药物长期以来一直被用于预防冠心病(CAD)。除了降低胆固醇外，它们的有益作用还在于它们的多效性。来自实验室研究和临床试验的新证据也指出，炎症在动脉粥样硬化的开始和恶化中起着关键作用，而动脉粥样硬化是冠心病的主要原因。炎症标志物如超敏C反应蛋白和黏附分子在冠心病患者中的升高，并可作为预后的工具。众所周知，他汀类药物实际上可以降低这些制剂的循环水平，从而减缓炎症过程；有趣的是，并不是所有类型的他汀类药物都有相同的结果。因此，他汀类药物对动脉粥样硬化斑块形成和内皮细胞功能的抗炎作用尤为重要，因为这些药物实际上可以改善冠心病的预后。
Statins have long been used for the protection against coronary artery disease (CAD). Their beneficial effect apart from cholesterol reduction lies in their pleiotropic properties. Emerging evidence from laboratory studies and clinical trials as well have pointed out the pivotal role of inflammation on the initiation and exacerbation of atherosclerosis; a major cause of CAD. Inflam-mation markers such as high sensitivity C-reactive protein and adhesion molecules are shown to in-crease in CAD patients and are used as prognostic tools. It is well known that statins can actually re-duce the circulating levels of these agents slowing therefore the inflammatory process; interestingly not all types have the same outcome. The anti-inflammatory effect of statins on the formation of atherosclerotic plaque and the function of endothelial cells is thus of particular importance as these agents can actually ameliorate CAD prognosis