A brief history of artemisinin: Modes of action and mechanisms of resistance
A brief history of artemisinin: Modes of action and mechanisms of resistance
复制标题
青蒿素简史：作用方式和耐药机制
DOI：
10.1016/s1875-5364(19)30038-x
复制
发表时间：
2019-05-20
影响因子：
4.6
通讯作者：
Cao Jun
中科院分区：
文献类型：
--
作者：
Lu Feng;He Xin-Long;Cao Jun
抗疟治疗的基石青蒿素降低了全世界与疟疾有关的发病率和死亡率。然而，出现了对青蒿素敏感性降低的恶性疟原虫寄生虫，这威胁到疟疾控制和消除工作。在这篇简短的综述中，我们描述了青蒿素作为抗疟药物的最初发展，它在历史上和现在的使用，以及我们目前对它的作用方式和疟原虫获得耐药性的机制的理解。
The cornerstone of antimalarial treatment, artemisinin, has reduced malaria associated morbidity and mortality worldwide. However, Plasmodium falciparum parasites with reduced sensitivity to artemisinin have emerged, and this threatens malaria control and elimination efforts. In this minireview, we describe the initial development of artemisinin as an antimalarial drug, its use both historically and currently, and our current understanding of its mode of action and the mechanisms by which malaria parasites achieve resistance.