Seabuckthorn Leaves Extract and Flavonoid Glycosides Extract from Seabuckthorn Leaves Ameliorates Adiposity, Hepatic Steatosis, Insulin Resistance, and Inflammation in Diet-Induced Obesity.
Seabuckthorn Leaves Extract and Flavonoid Glycosides Extract from Seabuckthorn Leaves Ameliorates Adiposity, Hepatic Steatosis, Insulin Resistance, and Inflammation in Diet-Induced Obesity.
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DOI：
10.3390/nu9060569
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发表时间：
2017-06-02
期刊：
影响因子：
5.9
通讯作者：
Choi MS
中科院分区：
文献类型：
--
作者：
Kwon EY;Lee J;Kim YJ;Do A;Choi JY;Cho SJ;Jung UJ;Lee MK;Park YB;Choi MS
本研究的目的是阐明沙棘叶提取物（SL）和沙棘叶黄酮苷提取物（SLG）对饮食诱导的肥胖和相关代谢紊乱的影响，并通过比较SL和SLG的效果来确定黄酮苷和SL中的其他成分是否可以发挥可能的相互作用来预防代谢性疾病。给C57 BL/6 J小鼠喂食正常饮食（ND，AIN-93 G纯化饮食）、高脂肪饮食（HFD，60 kcal%脂肪）、HFD + 1.8%（w/w）SL（SL）和HFD + 0.04%（w/w）SLG（SLG）12周。在高脂喂养的小鼠中，SL和SLG通过抑制脂肪组织中的脂肪生成来降低肥胖，同时增加能量消耗。SL和SLG还通过抑制肝脏脂肪生成和脂质吸收来改善肝脏脂肪变性，同时还增强肝脏脂肪酸氧化，这可能与血脂异常的改善有关。此外，SL和SLG通过抑制血浆GIP水平来改善胰岛素敏感性，所述血浆GIP水平由分泌的促炎细胞因子和肝生糖酶活性调节。SL，特别是其黄酮苷（SLG），可以防止饮食诱导的肥胖（DIO）及其代谢并发症，如肥胖，血脂异常，炎症，肝脂肪变性和胰岛素抵抗的有害影响。
The aim of the current study was to elucidate the effect of seabuckthorn leaves (SL) extract and flavonoid glycosides extract from seabuckthorn leaves (SLG) on diet-induced obesity and related metabolic disturbances, and additionally, to identify whether flavonoid glycosides and other components in SL can exert a possible interaction for the prevention of metabolic diseases by comparing the effect of SL and SLG. C57BL/6J mice were fed a normal diet (ND, AIN-93G purified diet), high-fat diet (HFD, 60 kcal% fat), HFD + 1.8% (w/w) SL (SL), and HFD + 0.04% (w/w) SLG (SLG) for 12 weeks. In high fat-fed mice, SL and SLG decreased the adiposity by suppressing lipogenesis in adipose tissue, while increasing the energy expenditure. SL and SLG also improved hepatic steatosis by suppressing hepatic lipogenesis and lipid absorption, whilst also enhancing hepatic fatty acid oxidation, which may be linked to the improvement in dyslipidemia. Moreover, SL and SLG improved insulin sensitivity by suppressing the levels of plasma GIP that were modulated by secreted resistin and pro-inflammatory cytokine, and hepatic glucogenic enzyme activities. SL, especially its flavonoid glycosides (SLG), can protect against the deleterious effects of diet-induced obesity (DIO) and its metabolic complications such as adiposity, dyslipidemia, inflammation, hepatic steatosis, and insulin resistance.