Inflammation-sensitive plasma proteins, diabetes, and mortality and incidence of myocardial infarction and stroke -: A population-based study
Inflammation-sensitive plasma proteins, diabetes, and mortality and incidence of myocardial infarction and stroke -: A population-based study
复制标题
DOI：
10.2337/diabetes.52.2.442
复制
发表时间：
2003-02-01
期刊：
影响因子：
7.7
通讯作者：
Lindgärde, F
中科院分区：
文献类型：
--
作者：
Engström, G;Stavenow, L;Lindgärde, F
本研究探讨炎症敏感血浆蛋白(ISPs)与糖尿病患病率的关系，以及ISPs与糖尿病在预测死亡、心肌梗死和中风发生率方面的相互关系。对6,050名年龄在28-61岁的男性进行了血浆纤维蛋白原、α1-抗胰蛋白酶、结合珠蛋白、铜蓝蛋白和类粘蛋白的检测。在18.7+/-3.7年的时间里监测了全因死亡率和心血管死亡率以及心肌梗塞和中风的发生率。在超重和肥胖男性中，糖尿病患病率(n=321)与isp水平显著相关，但在体重指数(BMI)男性中则无关
This study explores the relationship of inflammation-sensitive plasma proteins (ISPs) with the prevalence of diabetes and the interrelationships between ISPs and diabetes in the prediction of death and incidence of myocardial infarction and stroke. Plasma levels of fibrinogen, alpha1-antitrypsin, haptoglobin, ceruloplasmin, and orosomucoid were assessed in 6,050 men, aged 28-61 years. All-cause and cardiovascular mortality and incidence of myocardial infarction and stroke were monitored over 18.7 +/- 3.7 years. Prevalence of diabetes (n = 321) was significantly associated with ISP levels among overweight and obese men but not among men with BMI