REACTIONS OF METHYLNITROSOUREA, EPICHLOROHYDRIN, STYRENE OXIDE AND ACETOXYACETYLAMINOFLUORENE WITH POLYAMINO ACIDS
REACTIONS OF METHYLNITROSOUREA, EPICHLOROHYDRIN, STYRENE OXIDE AND ACETOXYACETYLAMINOFLUORENE WITH POLYAMINO ACIDS
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DOI：
10.1093/carcin/4.1.1
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发表时间：
1983-01-01
期刊：
影响因子：
4.7
通讯作者：
HEMMINKI, K
中科院分区：
文献类型：
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作者：
HEMMINKI, K
用放射性甲基亚硝基脲、环氧氯丙烷、氧化苯乙烯和n -乙酰氧基-2-乙酰氨基芴与14种不同的多氨基酸进行体外反应，测定氨基酸中官能团的相对反应活性。所有致癌物都优先与聚半胱氨酸反应，而与聚组氨酸反应则少得多。还注意到与聚赖氨酸、聚蛋氨酸和聚精氨酸以及DNA的反应。环氧氯丙烷和氧化苯乙烯也与聚丝氨酸反应。与环氧化物相比，甲基亚硝基脲和n -乙酰氧基-2-乙酰氨基芴与多组氨酸的反应相对较多。在pH为8时，聚半胱氨酸、聚组氨酸和聚赖氨酸对苯乙烯的反应比在pH为6时更明显。
Radioactive methylnitrosourea, epichlorohydrin, styrene oxide and N-acetoxy-2-acetylaminofluorene were reacted with 14 different polyamino acids in vitro, to determine the relative reactivity of the functional groups in amino acids. All the carcinogens reacted preferentially with polycysteine and much less with polyhistidine. Reaction was also noted with polylysine, polymethionine and polyarginine, as well as with DNA. Epichlorohydrin and styrene oxide reacted also with polyserine. Methylnitrosourea and N-acetoxy-2-acetylaminofluorene reacted relatively more with polyhistidine as compared with the epoxides. Polycysteine, polyhistidine and polylysine were more reactive towards styrene oxide at pH 8 than at pH 6.