Severe osteoporosis before and after lung transplantation
Severe osteoporosis before and after lung transplantation
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DOI：
10.1378/chest.109.5.1176
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发表时间：
1996-05-01
期刊：
影响因子：
9.6
通讯作者：
Ontjes, D
中科院分区：
文献类型：
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作者：
Aris, RM;Neuringer, IP;Ontjes, D
研究目的：骨质疏松症和/或骨折已被报道为肾、心、肝、骨髓和最近肺移植(LTX)的并发症。患者和方法：我们对100例不同诊断的患者进行了LTX前(n=55)和后(n=45)的BMD横断面研究。结果：LTX前后年龄匹配的平均脊柱和股骨骨密度严重降低，分别为LTX前的45%和LTX后的73%，达到或低于骨折阈值(低于平均值2个标准差)。正如预期的那样，囊性纤维化症患者的死亡率较低(p
Study objective: Osteoporosis and/or fractures have been reported as a complication of kidney, heart, liver, bane marrow, and, most recently, lung transplantation (LTx). We measured bone mineral density (BMD) before and after LTx to determine the frequency and severity of preoperative and postoperative osteoporosis.Patients and methods: We conducted a cross-sectional study of BMD in 100 patients with various diagnoses before (n=55) and after (n=45) LTx.Results: Age-matched mean spine and femoral BMDs were severely depressed before and after LTx placing 45% of the pre-LTx and 73% of the post-LTx patients at or below the fracture threshold (2 SDs below the mean). As expected, patients with cystic fibrosis had lower (p