Calcitonin, somatostatin and ACTH immunoreactive cells in a case of familial bilateral thyroid medullary carcinoma
Calcitonin, somatostatin and ACTH immunoreactive cells in a case of familial bilateral thyroid medullary carcinoma
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降钙素、生长抑素及ACTH免疫反应细胞在一例家族性双侧甲状腺髓样癌中的作用
作者：
C. Charpin;L. Andrac;M. Monier‐Faugere;J. Hassoun;M. Cannoni;J. Vagneur;M. Toga
双侧甲状腺髓样癌 (MCT) 是在 MCT 高危家族的一名无症状患者中发现的。血清降钙素升高对五肽胃泌素反应异常导致甲状腺切除术。大体上，甲状腺在每个叶的上三分之一处显示一个结节。光学显微镜显示典型的 MCT 具有淀粉样蛋白沉积物。非肿瘤甲状腺组织显示C细胞滤泡旁增生。电子显微镜检测到细胞内分泌颗粒（平均直径，150 nm）和典型的淀粉样原纤维。免疫化学显示结节、正常滤泡旁和滤泡内 C 细胞以及增生 C 细胞中存在大量降钙素免疫反应细胞。在某些肿瘤细胞中检测到生长抑素和 ACTH，但在正常和增生 C 细胞中未检测到。讨论了 MCT 的激素产生潜力。癌症 50：1806-1184，1982 年。
Bilateral medullary carcinoma of the thyroid (MCT) was discovered in a symptomless patient of a high‐risk MCT family. Raised serum calcitonin responding abnormally to pentagastrin led to a thyroidectomy. Grossly, the thyroid showed one nodule in the upper third of each lobe. Light microscopy revealed typical MCT with amyloid deposits. Nontumoral thyroid tissue showed C cell parafollicular hyperplasia. Electron microscopy detected intracellular secretory granules (mean diameter, 150 nm) and typical amyloid fibrills. Immunochemistry revealed numerous calcitonin immunoreactive cells in the nodules, in normal para and intrafollicular C‐cells and hyperplasic C‐cells. Somatostatin and ACTH were detected in certain tumor cells, but not in normal and hyperplasic C‐cells. MCT hormonal production potential is discussed. Cancer 50:1806‐1184, 1982.