Marked Decline in Trabecular Bone Mineral Content in Healthy Men with Age: Lack of Association with Sex Steroid Levels
Marked Decline in Trabecular Bone Mineral Content in Healthy Men with Age: Lack of Association with Sex Steroid Levels
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健康男性的骨小梁矿物质含量随着年龄的增长而显着下降：与性类固醇水平缺乏关联
DOI：
10.1111/j.1532-5415.1987.tb02308.x
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发表时间：
1987
影响因子：
6.3
通讯作者：
R. Fagerstrom
中科院分区：
文献类型：
--
作者：
D. Meier;E. Orwoll;E. Keenan;R. Fagerstrom
为了确定年龄相关的骨矿物质含量变化与正常男性性腺功能的关系，我们测量了62名年龄在30至92岁之间的健康受试者的桡骨（主要是皮质）和椎骨（主要是小梁）骨矿物质含量（BMC），睾酮（总睾酮和游离睾酮），雌酮和雌二醇-17 B水平。桡骨BMC每10年下降2 - 3.4%，但椎体骨小梁BMC下降更快，每10年下降12%。在测量的性类固醇中，唯一有统计学意义的变化发生在游离睾酮水平上，它随年龄的增长而下降（r =-0.57，P <0.0001）。游离睾酮水平与骨小梁BMC显著相关（r = 0.458，P <0.0002），但与以皮质为主的桡骨部位的骨矿物质测量值无关。然而，通过多元回归分析，游离睾酮并没有增加年龄对椎体BMC的影响。在这些健康男性的三个测量部位中，总睾酮、雌酮或雌二醇水平与骨矿物质含量均无相关性。男性性腺功能的年龄相关性下降似乎在男性年龄相关性骨质流失中并不重要。
To define the association of age‐related changes in bone mineral content to gonadal function in normal men, we measured radial (largely cortical) and vertebral (largely trabecular) bone mineral content (BMC), testosterone (total and free), estrone and estradiol‐17B levels in 62 healthy subjects, ages 30 to 92. Radial BMC fell 2 to 3.4% per decade but vertebral trabecular BMC declined more rapidly at 12% per decade. Of the sex steroids measured the only statistically significant change occurred in free testosterone levels which decreased with age (r = −.57, P < .0001). Free testosterone levels correlated significantly with trabecular vertebral BMC (r = .458, P < .0002) but not with bone mineral measures at the predominantly cortical radial sites. However, by multiple regression analysis free testosterone did not add to the effect of age on vertebral BMC. There were no associations of total testosterone, estrone, or estradiol levels to bone mineral content at any of the three sites measured in these healthy men. Age‐related declines in male gonadal function do not appear to be of primary importance in male age‐related bone loss.
患有髋部骨折的绝经后妇女的总雌激素和游离雌激素和雄激素。
DOI：
10.1210/jcem-54-1-115
发表时间：
1982
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Davidson,BJ;Ross,RK;Paganini-Hill,A;Hammond,GD;Siiteri,PK;Judd,HL
通讯作者：
Judd,HL
影响因子：
15.9
作者：
RIGGS, BL;WAHNER, HW;MELTON, LJ
通讯作者：
MELTON, LJ