BioGRID: A Resource for Studying Biological Interactions in Yeast.
BioGRID: A Resource for Studying Biological Interactions in Yeast.
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DOI：
10.1101/pdb.top080754
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发表时间：
2016-01-04
影响因子：
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通讯作者：
Tyers M
中科院分区：
文献类型：
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作者：
Oughtred R;Chatr-aryamontri A;Breitkreutz BJ;Chang CS;Rust JM;Theesfeld CL;Heinicke S;Breitkreutz A;Chen D;Hirschman J;Kolas N;Livstone MS;Nixon J;O'Donnell L;Ramage L;Winter A;Reguly T;Sellam A;Stark C;Boucher L;Dolinski K;Tyers M
相互作用数据集生物通用存储库（BioGRID；www.thebiogrid.org）是一个免费的公共数据库，为生物和生物医学研究界提供精选的蛋白质和遗传相互作用数据。结构化的实验证据代码、直观的搜索界面和可视化工具能够发现单个基因、蛋白质或生物网络功能。 BioGRID 保存了主要模型生物物种（包括酵母、线虫、苍蝇、斑马鱼、小鼠和人类）的相互作用数据，特别强调芽殖酵母酿酒酵母和裂殖酵母裂殖酵母作为网络生物学的先驱真核模型。 BioGRID 已经实现了对这两种主要酵母模型的整个文献的全面管理覆盖，并通过每月的管理更新来积极维护。截至 2014 年 12 月，BioGRID 包含大约 349,000 个出芽酵母的生物相互作用，以及 69,700 个裂殖酵母的生物相互作用。 BioGRID 还支持集成的翻译后修饰 (PTM) 查看器，其中包含通过其姊妹数据库 PhosphoGRID (www.phosphogrid.org) 整理的 20,100 多个酵母磷酸化位点。该协议描述了如何使用 BioGRID 网站查询任何感兴趣基因的遗传或蛋白质相互作用，如何使用嵌入式交互式网络查看器可视化相关相互作用，以及如何下载选定相互作用或整个 BioGRID 相互作用数据集的数据文件。
The Biological General Repository for Interaction Datasets (BioGRID; www.thebiogrid.org) is a freely available public database that provides the biological and biomedical research communities with curated protein and genetic interaction data. Structured experimental evidence codes, an intuitive search interface and visualization tools enable the discovery of individual gene, protein or biological network function. BioGRID houses interaction data for the major model organism species - including yeast, nematode, fly, zebrafish, mouse and human - with particular emphasis on the budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe as pioneer eukaryotic models for network biology. BioGRID has achieved comprehensive curation coverage of the entire literature for these two major yeast models, which is actively maintained through monthly curation updates. As of December 2014, BioGRID houses approximately 349,000 biological interactions for budding yeast, and 69,700 interactions for fission yeast. BioGRID also supports an integrated post-translational modification (PTM) viewer that incorporates over 20,100 yeast phosphorylation sites curated through its sister database, the PhosphoGRID (www.phosphogrid.org). This protocol describes how to use the BioGRID website to query genetic or protein interactions for any gene of interest, how to visualize the associated interactions using an embedded interactive network viewer, and how to download data files for either selected interactions or the entire BioGRID interaction data set.