PORPHYRIN-LIPOPROTEIN ASSOCIATION AS A FACTOR IN PORPHYRIN LOCALIZATION
PORPHYRIN-LIPOPROTEIN ASSOCIATION AS A FACTOR IN PORPHYRIN LOCALIZATION
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DOI：
10.1016/0304-3835(86)90023-6
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发表时间：
1986-11-01
期刊：
影响因子：
9.7
通讯作者：
KESSEL, D
中科院分区：
文献类型：
--
作者：
KESSEL, D
全身性给予肿瘤定位产物血卟啉衍生物（HPD）的小鼠携带的路易斯肺肿瘤导致的血浆脂蛋白和白蛋白中的初始分布的血卟啉。HPD的更疏水的组分（包括肿瘤定位部分）优先结合血浆低密度脂蛋白（LDL）和高密度脂蛋白（HDL）。48小时后，剩余的血浆卟啉主要与HDL结合。HPD的分布模式与不同组织中LDL受体的相对数量有关。
Systemic administration of the tumor-localizing product hematoporphyrin derivative (HPD) to mice bearing the Lewis-Lung tumor leads to an initial distribution of prophyrins among plasma lipoproteins and albumin. The more hydrophobic components of HPD (including the tumor-localizing fraction) preferentially bind to plasma low density lipoprotein (LDL) and high density lipoprotein (HDL). After 48 h, the remaining plasma porphyrins are mainly bound to HDL. The distribution pattern of HPD is correlated with the relative numbers of LDL receptors in different tissues.