Daily aspirin use and prostate cancer risk in a large, multiracial cohort in the US
Daily aspirin use and prostate cancer risk in a large, multiracial cohort in the US
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DOI：
10.1023/a:1015788502099
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发表时间：
2002-06-01
影响因子：
2.3
通讯作者：
Stanford, JL
中科院分区：
文献类型：
--
作者：
Habel, LA;Zhao, W;Stanford, JL
目的：在一个大型的、种族多样的男性队列中，研究每日服用阿司匹林与前列腺癌风险之间的关系，随访时间长达32年。方法：研究人群包括90,100名Kaiser Permanente医疗保健计划的男性订户，他们在1964年至1973年期间接受了一次或多次多相健康检查。这项一般健康检查包括一份自我完成的调查问卷，要求男性记录他们在过去一年中是否几乎每天服用超过六片阿司匹林。使用当地肿瘤登记处随访受试者的前列腺癌发展。采用考克斯回归分析方法计算相对危险度（RR）和95%可信区间（CI）。其中，1617人患有局部阶段疾病，719人在诊断时患有区域或远处疾病。共有2466名男性（2.7%）报告在过去一年中几乎每天都在一次或多次健康检查中服用超过六片阿司匹林。在调整出生年份、教育、种族和健康检查次数后，与阿司匹林使用量相关的前列腺癌相对风险为0.76（95%CI 0.60-0.98）。相对风险并没有不同的种族和相似的局部阶段和区域或远程阶段prostate cancer.Conclusion：结果从我们的大型，多种族队列研究支持一个适度的反关系，每天消费超过6阿司匹林和前列腺癌的风险。
Objective: To examine the relationship between daily aspirin use and risk of prostate cancer in a large, racially diverse cohort of men followed for up to 32 years.Methods: The study population included 90,100 male subscribers to the Kaiser Permanente Medical Care Program who had received one or more multiphasic health checkups between 1964 and 1973. This general health checkup included a self-completed questionnaire that requested men to record if they took more than six aspirin almost every day during the previous year. Subjects were followed for the development of prostate cancer using the local tumor registry. Cox regression was used to estimate relative risks (RR) and 95% confidence intervals (CI).Results: A total of 2574 men developed prostate cancer. Of these, 1617 had local stage disease and 719 had either regional or distant disease at diagnosis. A total of 2466 men (2.7%) reported taking more than six aspirin almost every day during the past year at one or more health checkups. After adjusting for birth year, education, race, and the number of health checkups, the relative risk of prostate cancer associated with this amount of aspirin use was 0.76 (95% CI 0.60-0.98). Relative risks did not differ by race and were similar for both local stage and regional or distant stage prostate cancer.Conclusion: Results from our large, multiracial cohort study support a modest inverse relationship between daily consumption of more than six aspirin and prostate cancer risk.