Comparison of blood particle deposition models for non-parallel flow domains
Comparison of blood particle deposition models for non-parallel flow domains
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DOI：
10.1016/s0021-9290(02)00434-7
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发表时间：
2003-03-01
影响因子：
2.4
通讯作者：
Kleinstreuer, C
中科院分区：
文献类型：
--
作者：
Longest, PW;Kleinstreuer, C
单核细胞和血小板粘附到血管表面，特别是在流动停滞、再循环和再附着的区域，是广泛的颗粒-壁相互作用中的重要初始事件，其显著影响狭窄病变和壁血栓的形成。许多近似可用于模拟单核细胞和血小板与血管表面的相互作用。对于血液颗粒粘附的模拟，本研究假设：（a）考虑有限颗粒尺寸和惯性的离散元方法在包括停滞、再循环和再附着的非平行流域的背景下是有利的;和（B）颗粒沉积的可能性可以有效地近似为与局部颗粒浓度，停留时间，和墙壁接近度。模型，如壁面剪切应力的相关性，多组分混合物的方法，和拉格朗日粒子跟踪与流体动力学粒子壁相互作用进行了评价。通过与单核细胞和血小板非平行轴对称悬浮流的可用实验数据集进行比较，确定了所选模型的定量性能。包括颗粒的对流-扩散运输、有限的颗粒尺寸和惯性以及近壁流体动力学相互作用在内的因素被发现显著影响血液颗粒沉积。在所研究的模型中，发现近壁停留时间方法对于单核细胞（r（2）= 0.74）和血小板（r（2）= 0.57）的沉积是特别有效的指标，因为在涉及相对大尺度几何形状和复杂流场的计算模拟中必须极大地近似纳米尺度物理和生化效应。(C)2003爱思唯尔科技有限公司版权所有。
Adhesions of monocytes and platelets to a vascular surface, particularly in regions of flow stagnation, recirculation, and reattachment, are a significant initial event in a broad spectrum of particle-wall interactions that significantly influence the formation of stenotic lesions and mural thrombi. A number of approximations are available for the simulation of both monocyte and platelet interactions with the vascular surface. For the simulation of blood particle adhesion, this study hypothesizes that: (a) the discrete element approach, which accounts for finite particle size and inertia, is advantageous in the context of non-parallel flow domains including stagnation, recirculation, and reattachment; and (b) the likelihood for particle deposition may be effectively approximated as being non-linearly proportional to local particle concentration, residence time, and wall proximity. Models such, as wall shear stress correlations, the multicomponent mixture approach, and Lagrangian particle tracking with and without hydrodynamic particle-wall interactions were evaluated. Quantitative performance of the selected models was established by comparisons to available experimental data sets for non-parallel axisymmetric suspension flows of monocytes and platelets. Factors including the convective-diffusive transport of particles, finite particle size and inertia, as well as near-wall hydrodynamic interactions were found to significantly influence blood particle deposition. Of the models studied, the near-wall residence time approach was found to be a particularly effective indicator for the deposition of monocytes (r(2) = 0.74) and platelets (r(2) = 0.57), given that nano-scale physical and biochemical effects must be greatly approximated in computational simulations involving relatively large-scale geometries and complex flow fields. (C) 2003 Elsevier Science Ltd. All rights reserved.