The motor cortex uses active suppression to sculpt movement
The motor cortex uses active suppression to sculpt movement
复制标题
DOI：
10.1126/sciadv.abb8395
复制
发表时间：
2020-08-01
期刊：
影响因子：
13.6
通讯作者：
Strick, Peter L.
中科院分区：
文献类型：
--
作者：
Griffin, Darcy M.;Strick, Peter L.
即使是最简单的动作也是由非常复杂的肌肉活动模式产生的。单个关节的快速、准确的运动是由一种刻板的模式产生的，这种模式包括对抗肌肉中任何先前存在的活动的减少。这种运动前的抑制是必要的，以防止拮抗肌与激动肌产生的相反运动。在这里，我们提供的证据表明，初级运动皮质(M1)发出一个命令信号，产生这种运动前抑制。因此，M1中的输出神经元不仅通过主动启动肌肉，也通过主动关闭肌肉，塑造了复杂的运动输出时空模式。
Even the simplest movements are generated by a remarkably complex pattern of muscle activity. Fast, accurate movements at a single joint are produced by a stereotyped pattern that includes a decrease in any preexisting activity in antagonist muscles. This premovement suppression is necessary to prevent the antagonist muscle from opposing movement generated by the agonist muscle. Here, we provide evidence that the primary motor cortex (M1) sends a command signal that generates this premovement suppression. Thus, output neurons in M1 sculpt complex spatiotemporal patterns of motor output not only by actively turning on muscles but also by actively turning them off.