Strongyloidiasis-Related Deaths in the United States, 1991-2006
Strongyloidiasis-Related Deaths in the United States, 1991-2006
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DOI：
10.4269/ajtmh.2010.09-0750
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发表时间：
2010-08-01
影响因子：
3.3
通讯作者：
Mascola, Laurene
中科院分区：
文献类型：
--
作者：
Croker, Curtis;Reporter, Roshan;Mascola, Laurene
本研究的目的是 1) 评估美国类圆线虫病的发病率，2) 评估人口和区域关联。 3) 将合并症确定为死亡危险因素 通过使用 1991-2006 年期间的死亡率数据进行了一项基于人群的病例对照研究。我们确定了 347 例圆线虫病死亡（每 1000 万人死亡 0.79 例。每年 14-29 例死亡），随着时间的推移，死亡人数略有下降。死亡主要发生在居住在美国东南部的老年人（中位年龄= 66 0 岁）、白人（57 6%）和西班牙裔（22 2%）男性（69.2%）中（49 3%）。相关健康状况包括慢性阻塞性肺病（28 7%。比值比[OR] = 40。95% 置信区间[CI] - 3 0-5 4）和人类感染免疫缺陷病毒 (12 5%. OR = 4 6. 95% CI = 2 7-7 9) 研究期间后半段 (1999-2006) 类圆线虫病死亡与慢性阻塞性肺疾病的关联性较小 (19 4%, OR = 1 2. 95% CI = 0 7-1 9)。但仍与人类免疫缺陷病毒感染相关（12·9%，OR = 2·8. 95% Cl = 1·3-6.0） 需要早期发现和治疗潜在类圆线虫病感染的高危患者，以降低类圆线虫病死亡率
The objective of this study was to 1) assess the incidence of strongyloidiasis in the United States, 2) evaluate demographic and regional associations. and 3) identify comorbid conditions as risk factors for death A population-based case control study was performed by using mortality data during 1991-2006 We identified 347 strongyloidiasis deaths (0.79 per 10 million deaths. 14-29 deaths per Year), which decreased slightly over time. Deaths occurred primarily among older (median age = 66 0 years), white (57 6%) and Hispanic (22 2%) men (69.2%), residing in the Southeastern United States (49 3%) Associated health conditions included chronic obstructive pulmonary disease (28 7%. odds ratio [OR] = 40. 95% confidence interval [CI] - 3 0-5 4) and infection with human immunodeficiency virus (12 5%. OR = 4 6. 95% CI = 2 7-7 9) Strongyloidiasis deaths in the second half of the study period (1999-2006) were less likely to be associated with chronic obstructive pulmonary disease (19 4%, OR = 1 2. 95% Cl = 0 7-1 9). but continued to be associated with human immunodeficiency virus infection (12 9%, OR = 2 8. 95% Cl = 1 3-6.0) Early detection and treatment of at-risk patients with latent strongyloidiasis infections is needed to reduce strongyloidasis mortality