Progressive regional atrophy in normal adults with a maternal history of Alzheimer disease
Progressive regional atrophy in normal adults with a maternal history of Alzheimer disease
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DOI：
10.1212/wnl.0b013e31820e7b74
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发表时间：
2011-03-01
期刊：
影响因子：
9.9
通讯作者：
Burns, Jeffrey M.
中科院分区：
文献类型：
--
作者：
Honea, Robyn A.;Swerdlow, Russell H.;Burns, Jeffrey M.
目的：除年龄外，家族史是阿尔茨海默病（AD）最重要的危险因素。这项纵向脑成像研究检查了是否有认知健康的老年受试者（FH+）和无（FH-）迟发性AD家族史的区域灰质萎缩的差异模式。作为KU脑老化项目的一部分，有母性史的认知完整的个体在基线和2年随访时，在年龄、性别、教育程度和简易精神状态检查（MMSE）评分方面相似的11例有AD病史（FHm，n = 11）、10例有AD病史（FHp，n = 10）或32例无AD病史（FH=，n = 32）的患者接受MRI检查。使用基于体素的自定义形态测定处理流来检查FH组之间萎缩的区域差异，控制年龄，性别和APOE β 4（APOE 4）状态。我们还分析了APOE 4相关的atrophysics.Results：认知正常FH+个人有显着增加全脑灰质萎缩和CSF扩张相比FH-。当FH+组被分开时，只有FHm与脑变化的纵向测量相关。此外，我们的基于体素的分析显示，FHm受试者的楔前叶和海马旁/海马区萎缩明显大于FH和FHp受试者，与APOE 4状态、性别和年龄无关。个人与s4等位基因有更多的区域萎缩在额叶皮层相比，s4 noncarriers.Conclusions：我们得出结论，FHm个人没有痴呆症有渐进性灰质体积减少在选择AD脆弱的大脑区域，特别是楔前叶和海马旁回。这些数据补充并扩展了FHm受试者局部脑代谢差异和淀粉样蛋白-β负荷增加的报告，这可能与发生AD的风险较高有关。神经病学（R）2011;76：822-829
Objective: Beyond age, having a family history is the most significant risk factor for Alzheimer disease (AD). This longitudinal brain imaging study examines whether there are differential patterns of regional gray matter atrophy in cognitively healthy elderly subjects with (FH+) and without (FH-) a family history of late-onset AD.Methods: As part of the KU Brain Aging Project, cognitively intact individuals with a maternal history (FHm, n = 11), paternal history (FHp, n = 10), or no parental history of AD (FH=, n = 32) similar in age, gender, education, and Mini-Mental State Examination (MMSE) score received MRI at baseline and 2-year follow-up. A custom voxel-based morphometry processing stream was used to examine regional differences in atrophy between FH groups, controlling for age, gender, and APOE epsilon 4 (APOE4) status. We also analyzed APOE4-related atrophy.Results: Cognitively normal FH+ individuals had significantly increased whole-brain gray matter atrophy and CSF expansion compared to FH-. When FH+ groups were split, only FHm was associated with longitudinal measures of brain change. Moreover, our voxel-based analysis revealed that FHm subjects had significantly greater atrophy in the precuneus and parahippocampus/hippocampus regions compared to FH- and FHp subjects, independent of APOE4 status, gender, and age. Individuals with an s4 allele had more regional atrophy in the frontal cortex compared to s4 noncarriers.Conclusions: We conclude that FHm individuals without dementia have progressive gray matter volume reductions in select AD-vulnerable brain regions, specifically the precuneus and parahippocampal gyrus. These data complement and extend reports of regional cerebral metabolic differences and increases in amyloid-beta burden in FHm subjects, which may be related to a higher risk for developing AD. Neurology (R) 2011;76:822-829