Loss of peroxisome function triggers necrosis
Loss of peroxisome function triggers necrosis
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DOI：
10.1016/j.febslet.2008.07.023
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发表时间：
2008-08-20
期刊：
影响因子：
3.5
通讯作者：
Madeo, Frank
中科院分区：
文献类型：
--
作者：
Jungwirth, Helmut;Ring, Julia;Madeo, Frank
衰老过程中过氧化物酶体功能的紊乱可导致各种退行性疾病。在这里，我们表明，在酵母缺失的PEX6，编码的蛋白质参与过氧化物酶体蛋白进口的一个关键步骤，导致活性氧的积累增加，并增强乙酸处理后的活力损失，并在早期稳定期。缺乏PEX6的衰老样酵母细胞的细胞死亡不依赖于凋亡的关键参与者Yca1p和Aif1p，而是显示坏死的标志物。因此，我们得出结论，过氧化物酶体功能的丧失导致一种形式的坏死性细胞死亡。(C)2008年欧洲生化学会联合会。由Elsevier B出版。V.保留所有权利。
Disturbance of peroxisome function can lead to various degenerative diseases during ageing. Here, we show that in yeast deletion of PEX6, encoding a protein involved in a key step of peroxisomal protein import, results in an increased accumulation of reactive oxygen species and an enhanced loss of viability upon acetic acid treatment and during early stationary phase. Cell death of ageing-like yeast cells lacking PEX6 does not depend on the apoptotic key players Yca1p and Aif1p, but instead shows markers of necrosis. Thus, we conclude that loss of peroxisomal function leads to a form of necrotic cell death. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.